细胞因子在抗梅毒免疫中的研究进展

Cytokines in anti-syphilis immunity

一期梅毒以Th1型细胞占优势,二期以Th2型细胞为优势.Th1细胞因子（白细胞介素2、干扰素y）可增强T细胞能力,促进感染梅毒螺旋体清除使皮损痊愈.随着疾病进展,Th1细胞因子降低,Th2细胞因子（白细胞介素4、白细胞介素10）增多,并对细胞免疫有抑制作用,造成感染梅毒螺旋体在体内长期潜伏.Th7细胞可分泌白细胞介素7,其在梅毒免疫中起作用.其他的细胞因子（干扰素、白细胞介素12）也在抗梅毒免疫反应中发挥重要作用.

T helper type 1 （Th1） cytokines predominate in primary syphilis,while Th2 cytokines predominate in secondary syphilis.Th1 cytokines such as interleukin （IL）-2 and interferon （IFN）-γ can enhance the ability of T cells to promote the clearance of Treponema pallidum （TP） and healing of skin lesions.Along with the progression of syphilis,Th1 cytokines decrease,while Th2 cytokines （including IL-4 and IL-10） increase to inhibit cellular immunity and result in long-term latency of TP infection in the body.Th7 cells can secrete IL-7 and exert a protective role in anti-syphilis immunity.Other kinds of cytokines including IFN and IL-12 also play important roles in anti-syphilis immune response.