血浆网膜素-1水平与结直肠癌的相关性研究

Correlation between plasma omentin-1 levels and colorectal cancer

目的探讨血浆脂肪因子网膜素-1(omentin-1)水平和结直肠癌(CRC)的相关关系。方法选取经术后病理检查明确诊断为CRC的患者42例(肿瘤组)和接受纤维结肠镜检查为正常的健康志愿者42例(对照组),两组间年龄、性别均匹配。采用ELISA法测定肿瘤组以及对照组空腹血浆omentin-1水平。结果与对照组相比,肿瘤组患者血浆omentin-1水平明显升高(P<0.05)。Pearson相关分析显示,血浆omentin-1与高密度脂蛋白胆固醇(HDL-C)呈正相关(r=0.57,P<0.01),与血清三酰甘油(TG)、空腹胰岛素(FINS)、腰臀比(WHR)、稳态模型胰岛素抵抗指数(HOMAIR)均呈负相关(r=-0.668、-0.493、-0.395、-0.371,P<0.05)。多元逐步线性回归分析显示,TG、HDL-C、WHR为CRC患者血浆omentin-1的影响因素。结论血浆omentin-1水平可能与CRC发生有关。

Objective To investigate the relationship between plasma adipocytokine omentin-1 levels and colorectal cancer （ CRC） . Methods This study was conducted among 42 patients with pathologically diagnosed CRC after operation as the case group, and 42 healthy subjects who underwent total colonoscopy because of a voluntary health check-up as the control group. The above two groups were matched between age and sex. After participants had fasted overnight,their blood samples were collected. Fasting plasma omentin-1 was measured using ELISA methods. Results The omentin-1 levels in patients with CRC were significantly higher than in controls （ P 〈0. 05 ） . Spearman correlation analysis showed that plasma omentin-1 was positively correlated with high density lipoprotein cholosterol （HDL-C） （r=0. 57,P〈0. 01）,and negatively correlated with serum triglyceride（TG）, fsating insulin （FINS）, waist hip ratio（WHR）, HOMA model insulin resistance index（HOMA-IR） （r = -0. 668,-0. 493,-0. 395,-0. 371,respectively, P〈0. 05）. Multiple stepwise regression analysis showed that TG, HDL-C, WHR were the influencing factors of plasma omentin-1 in CRC patients. Conclusion The plasma omentin-1 level may correlate with the development of CRC.