摘要
目的探讨应用99mTc-亚锡喷替酸(99mTc-DTPA)肾动态显像测定肾小球滤过率(GFR)、高峰时间(Tb)和半排时间(C1/2)联合尿β2-微球蛋白(β2-MG)含量测定,评估其在妇科肿瘤顺铂(DDP)化疗时肾功能早期损伤的诊断价值。方法用自身对照法对98例妇科肿瘤患者在首次化疗前与化疗2周期后行99mTc-DTPA肾动态显像,测定GFR、Tb、C1/2,同期测定血尿素氮(BUN)、肌酐(SCr)以及血、尿β2-MG含量。应用配对t检验对比观察。结果 98例患者化疗2周期后较化疗前GFR明显下降(P<0.05),而Tb、C1/2显著延长(P<0.01);尿β2-MG含量明显升高(P<0.01),而血中BUN、SCr、β2-MG变化均不明显。结论与测定血BUN、SCr、β2-MG含量比较,99mTc-DTPA肾动态显像测定GFR、Tb、C1/2及尿β2-MG含量,能发现含DDP化疗患者肾功能早期的损伤,对于临床合理用药、观察和保护肾功能有一定的参考价值。
Objective To explore the significance of ^99mTechnetium-diethyene triaminepentaacetic acid（^99mTc-DT-PA） renal dynamic imaging of glomerular filtration rate （ GFR） , apex time（ Tb） , half excretion time（ C1/2 ） and u-rine β2-microglobulin（β2-MG） determination in the evaluation of early renal function damage of patients with gyne-cological tumor after cis-diaminodichloroplatinum（ DDP） chemotherapy. Methods 98 cases of patients with gyne-cological tumor were enrolled in this study. Self-contrasted method was used. The data of GFR,Tb,C1/2 by ^99mTc-DTPA renal dynamic imaging and blood urea nitrogen （ BUN） ,serum creatinine （ SCr） levels in blood,β2-MG level in blood from pre-chemotherapy and post-two-period-chemotherapy were compared by paired t test. Results All cases showed a significant decrease in GFR（P〈0. 05）and a significant increase of Tb and C1/2（P〈0. 01） after two periods of chemotherapy and β2-MG in urine（P〈0. 01）,the changes of BUN,SCr and β2-MG levels in blood were not singnificant. Conclusion The changes of GFR,Tb, C1/2 by ^99mTc-DTPA renal dynamic imaging andβ2-MG level in urine precede those of BUN,SCr and β2-MG levels in blood, which will be helpful to evaluate the early renal function damage caused by DDP chemotherapy in patients with gynecologic tumors, and rational admin-istration and the observation and protection of renal function.
出处
《安徽医科大学学报》
CAS
北大核心
2015年第1期108-111,共4页
Acta Universitatis Medicinalis Anhui
基金
卫生部核医学重点实验室江苏省分子核医学重点实验室开放课题(编号:KF201301)
