李振华治疗慢性萎缩性胃炎用药的数据挖掘分析

Drug analysis of Li zhenhua for the treatment of chronic atrophic gastritis based on the data mining

目的：运用数据挖掘、整理分析的方法总结李振华教授治疗慢性萎缩性胃炎（CAG）的用药经验。方法收集整理李教授诊治有效的139例CAG患者的病历资料。运用SPSS软件，进行数据提取录入-分析-描述统计，统计主要证型、主要方剂、用药频率；从而得出CAG常用药物、总结常用方剂及用药规律。结果数据分析结果显示，李教授对CAG证型主要包括肝胃不和证、脾胃湿热证、脾虚湿热证、肝郁脾虚证、脾胃虚弱证、肝胃阴虚气滞证、肝胃郁热证和胃络瘀血证；常用代表方剂为小柴胡汤、四逆散、柴胡桂枝龙骨牡蛎汤、柴胡疏肝散、黄连温胆汤、半夏泻心汤、逍遥散、香砂六君子汤等；常用药物从高到低依次为柴胡、白芍、陈皮、炙甘草、茯苓、黄芩、生姜、炒白术、黄连、法半夏、生甘草、百合、焦三仙、香附、太子参、乌药、大枣、党参、枳实、清半夏、生牡蛎等。结论李教授重视从肝论治脾胃病，清热化湿和脾胃，辨证应用补气健脾、理气消导、活血消癥等法；为学习其用药经验及治疗思路提供了数据支持。

Objective The method of data mining and sorting analysis was used to analyze and summarize the drug experience of Professor Li Zhenhua in the treatment of chronic atrophic gastritis （CAG）. Methods Professor Li’s medical records of effective diagnosis and treatment of 139 CAG patients were collected. Find-Replace method of Microsoft office word 2007 was used to count the major syndromes and main prescription of CAG. SPSS statistical software was adopted to perform entry-analysis-descriptive statistics and data analysis of and main syndrome, main formula and frequency of administration so as to obtain the commonly used drugs, commonly used prescription and drug laws of CAG. Results Professor Li Zhenhua believed that the clinical syndromes of CAG included the disharmony of liver-stomach-spleen syndrome, the damp heat of spleen-stomach syndrome, the deficiency and damp heat of spleen syndrome, the liver depression and spleen deficiency syndrome, the deficiency of spleen-stomach syndrome, the liver and stomach yin deficiency and qi stagnation syndrome, the stagnant heat of liver-stomach syndrome and the blood stasis of stomach meridian syndrome;the commonly used drugs were：bupleurum, white peony root, orange peel, licorice, poria, skullcap, ginger, fried atractylodes, golden thread, prepared pinellia, licorice, lily, stir-baking Sanxian, nutgrass galingale rhizome, heterophylly falsesatarwort root, combined spicebush root, Chinese date, tangshen, immature orange fruit, prepared rhizome pinellize without adjuvant, and oyster shell..The commonly used prescriptions were： Xiaochaihu decoction, Sini powder, Chaihu-Guizhi-Longgu-Muli decoction, Chaihu-Shugan powder, Huanglian-Wendan decoction, Banxia-Xiexin decoction, Xiaoyao powder, Xiangsha-Liujunzi decoction.＆amp;nbsp;Conclusion Professor Li pay attention to treat spleen and stomach disease from liver by clearing heat and removing dampness from spleen and stomach. He used the dialectical methods like invigorating qi and strengthening the spleen, regulating qi digestion, activating blood flow to eliminating blood stasis.