甲泼尼龙早期短程冲击疗法与地塞米松治疗小儿重症病毒性脑炎的疗效对比

Comparative Efficacy of Early Short Methylprednisolone Pulse Therapy and Dexamethasone in Treatment of Children with Severe Viral Encephalitis

目的:探讨甲泼尼龙早期短程冲击疗法与地塞米松治疗小儿重症病毒性脑炎的疗效。方法:收集2012年6月-2014年6月来本院进行救治的重症病毒性脑炎患儿120例,按照数字列表法随机平均分为观察组和对照组,其中观察组采用甲泼尼龙早期短程冲击疗法进行治疗,对照组采用地塞米松治疗,比较两组患者的症状、体征恢复时间,以及临床疗效。结果:(1)观察组患者的临床症状及体征恢复时间明显短于对照组的恢复时间,比较差异有统计学差异(P<0.05);(2)观察组患者的效果优良率为96.67%,高于对照组的75.00%,比较差异有统计学差异(P<0.05)。结论:采用甲泼尼龙早期短程冲击疗法治疗小儿重症病毒性脑炎有确切临床疗效,并且可尽快恢复患者体征及症状。

Objective：To investigate the efficacy of early short methylprednisolone pulse therapy and dexamethasone in treatment of children with severe viral encephalitis.Method：120 cases with severe viral encephalitis were selected from our hospital during the period from June 2012 to June 2014, they were randomly divided into observation group and control group accordance to a digital list france, the observation group was early methylprednisolone pulse therapy using short, the control group was treated with dexamethasone, the symptoms and signs the recovery time, and clinical efficacy of the two groups were compared.Result：（1） Clinical symptoms and signs recovery time of the observation group was significantly shorter than recovery time of the control group, the difference was statistically significant（P〈0.05）.（2） Effect good rate of the observation group was significantly higher than the that of the control group, the difference was statistically significant（P〈0.05）.Conclusion：Early short methylprednisolone pulse therapy in treatment of children with severe viral encephalitis has exact clinical efficacy, and can be restored as soon as the patient signs and symptoms.