摘要
丙烯酸乙酯与哌啶经加成反应制得3-(1-哌啶基)丙酸乙酯(1);1与格氏试剂苯基溴化镁反应制得普立地诺(2);2与甲磺酸反应合成了普立地诺甲磺酸盐,总收率70.3%,其结构经1H NMR,13C NMR和MS确证。
Ethyl 3-（1-piperidinyl） propionate（1） was prepared by addition reaction of ethyl acrylate with piperidine. Pridinol mesylate with the total yield of 70. 3% was synthesized by Grignard reaction of 1 with phenylmagnesium bromide,then by acidification with mesylate. The structure was confirmed by^1 H NMR,^13 C NMR and MS.
出处
《合成化学》
CAS
CSCD
2015年第2期167-168,171,共3页
Chinese Journal of Synthetic Chemistry
基金
教育部留学回国人员科研基金资助项目{教外司留[2013]179号}
宁波市自然科学基金资助项目(2013A610094)
浙江省公益技术项目(2014C31128)
