壳聚糖水胶体敷贴治疗睑皮肤裂伤的临床研究

Clinical research of chitosan hydrocolloid dressings in the management for eyelid skin lacerations

目的探讨壳聚糖水胶体敷贴（3T愈创宁）治疗眼睑皮肤裂伤的临床效果。方法将眼睑皮肤裂伤142例（142眼）随机分为A组与B组，每组各71例。两组均做常规清创缝合，A组缝合后予以壳聚糖水胶体敷贴贴敷伤口并加盖无菌敷料包扎。B组为对照组，缝合后直接予以无菌敷料包扎。观察两组皮肤裂伤的治愈率和治愈时间。结果两组眼睑皮肤裂伤患者均治愈，均未出现伤口继发感染。A组皮肤裂伤愈合时间为4．5～8．2d，平均（5．71±0．76）d；B组皮肤裂伤愈合时间5．9～11．5d，平均（8．50±2．14）d。A组疗程显著短于B组，差异有统计学意义（P〈0．05）。结论应用壳聚糖水胶体敷贴治疗眼睑裂伤方法，可明显缩短眼睑皮肤裂伤的愈合时间。

Objective To investigate the clinical efficacy of chitosan hydrocolloid dressings in the management of eyelid skin lacerations. Methods A comparative, prospective and randomized clinical trial was performed in 142 eyes of 142 patients with eyelid skin lacerations. All patients were randomly divided into two groups with 71 eyes of 71 patients in each group. In group A, patients were received debridement and suturing , then covered with chitosan hydrocolloid dressings . In group B, patients were received debridement and suturing , then covered with ordinary dressings. Patients were followed up for 1 to 3 months. The cure rate and cure time was observed and compared between two groups. Results No significant infection occurred in all patients. The average cure time was（ 5.71 ± 0.76） days for group A and （8.50 ± 2.14） days for group B and the difference was statistically significant （P 〈 0.05 ）. Conclusion Chitosan hydrocolloid dressings for the management of eyelid skin lacerations can shorten the cure time in patients with eyelid skin lacerations.