摘要
目的:研究"肤敏膏"对豚鼠湿疹皮炎模型皮肤组织病理学的影响,探讨其治疗作用及机理。方法:以2,4-二硝基氯苯(DNFB)建立豚鼠湿疹皮炎模型,采用HE常规病理及透射电镜超微病理学检测方法,观察"肤敏"膏对实验性豚鼠湿疹皮炎的治疗作用。结果:"肤敏膏"能改善动物湿疹皮炎模型皮肤组织病变,减少炎性细胞浸润。结论:"肤敏膏"对Th1/Th2细胞平衡失调所引起的后续皮肤炎症反应和组织损伤有明显抑制作用,从而间接调节Th1/Th2细胞动态平衡,改善过敏症状。
Objective： To investigate the influence ofFuMincream on skin pathology of guinea pigs suffering from eczematous dermatitis, explore its therapeutic function and the pathogenesis. Methods： Models were prepared by DNFB, curative effects ofFuMincream on the models were observed by HE staining method and ultrastructural pathological detection of transmission electron microscope. Results： FuMin cream could improve skin pathological changes of the animals with eczematous dermatitis and reduce inflammatory cells infiltration. Conclusion：FuMin cream could inhibit inflammatory reaction and tissue damage significantly induced by the imbalance of TH1/Th2 cells, consequently, regulate dynamic balance of TH1/Th2 cells indirectly and improve allergic symptoms.
出处
《西部中医药》
2015年第1期13-15,共3页
Western Journal of Traditional Chinese Medicine
关键词
湿疹皮炎
豚鼠
肤敏膏
eczematous dermatitis
guinea pig
FuMincream
