应用米索前列醇引产对新生儿血清总胆红素的影响

Impact of misoprostol using in labor induction of prolonged pregnancy on the serum total bilirubin of neonates

目的探讨对超过预产期产妇应用米索前列醇引产对新生儿血清总胆红素的影响。方法选择2010年12月至2012年12月在沈阳市沈河区妇幼保健所出生的因超过预产期引产的新生儿155例,其中无药物引产(A组)50例,催产素引产(B组)52例,米索前列醇引产(C组)53例,测定3组新生儿出生后24 h、96 h微量血清总胆红素。结果 3组新生儿出生后24 h、96 h微量血清总胆红素水平分别为:A组(47.3±1.8)umol/L、(173.9±5.9)umol/L,B组(55.8±2.1)umol/L、(198.9±6.1)umol/L,C组(64.2±2.7)umol/L、(230.9±6.1)umol/L。新生儿微量血清总胆红素水平A组低于B组、C组(P<0.05);A组、B组新生儿高胆红素血症发生率、新生儿窒息发生率低于C组(P<0.05)。结论米索前列醇用于引产可导致新生儿血清胆红素升高。

Objective To explore the impact of misoprostol using in labor induction of prolonged pregnancy on the serum total bilirubin of neonates .Methods 155 neonates of induced labor in Maternal and Child Health Care Institution of Shenhe District in Shenyang City from Dec.2010 to Dec.2012 were selected, Group A（n =50）, Group B（n =52） and Group C（n =53） who conducted induced labor with no drug , oxytocin and misoprostol separately .The serum total bilirubin were measured for neonates 24h, 96h after birth.Results The serum total bilirubin of neonates 24h, 96h after birth of 3 groups：group A were（47.3 ±1.8）umol/L, （173.9 ±5.9）umol/L, group B were（55.8 ±2.1）umol/L,（198.9 ±6.1）umol/L, group C were（64.2 ±2.7）umol/L,（ 230.9 ± 6.1）umol/L.The serum total bilirubin of neonates of group A was lower than group B and group C （P〈0.05）, The incidence of neonatal hyperbilirubinemia and neonatal asphyxia of group A and group B were lower than group C （ P 〈0.05 ） .Conclusion Misoprostol using in labor induction of prolonged pregnancy may cause a increase of serum bilirubin of neonates .