慢性阻塞性肺疾病急性加重期患者血清α1-AT及CRP检测的临床意义

Clinical Significance of α1-AT and CRP Detection in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Diseases

目的:研究血清α1-AT及CRP水平检测在慢性阻塞性肺疾病(COPD)急性加重期患者中的临床意义。方法:将本院收治的64例AECOPD患者随机数字表法分为对照组和观察组,两组患者均给予基础治疗、雾化吸入沙丁胺醇和异丙托溴铵治疗。观察组在对照组治疗基础上,加用布地奈德雾化吸入治疗。治疗7 d后比较血清CRP和α1-AT水平,评定并比较临床疗效。结果:AECOPD组血清CRP显著高于COPD稳定期组(P<0.05),血清α1-AT水平与COPD稳定期组相当(P>0.05)。观察组和对照组患者治疗后CRP和α1-AT较治疗前均显著降低(P<0.05),观察组CRP降低幅度更大,治疗后CRP水平明显小于对照组(P<0.05),但两组之间α1-AT的差异比较无统计学意义(P>0.05)。结论:CRP可作为反应COPD病情严重程度的敏感性指标,联合与α1-AT检测,对COPD的诊断和疗效判断具有一定的临床应用价值。

Objective： To observe the clinical effect alpha1-antitrypsin（α1-AT） and serum C reactive protein（CRP） levels in patients with acute exacerbation chronic obstructive pulmonary disease（COPD）. Method： 64 patients with AECOPD in our hospital were chosen and divided randomly to observation group and control group, which all treated by basis treatment and pulverization inhalation treatment with salbutamol and ipratropium bromide. Patients in observation group were also given pulverization inhalation treatment of budesonide. The levels of serum CRP and α1-AT were compared after seven days treatment, and the clinical effects were evaluated and compared. Result： The CRP level of the AECOPD group was significantly higher than that of the stable COPD group（P〉0.05）, but the α1-AT level had no obviously differences between the two group（P〈0.05）. The levels of serum CRP and α1-AT significantly decreased after treatment, and the CRP level was significantly lower in observation group than that in the control group（P〈0.05）, while the α1-AT level between the two groups had no statistically significant differences（P〉0.05）. Conclusion： CRP is a sensitive indicator for the patients with COPD, combing with α1-AT associated detection, have clinical practical value for diagnose and therapeutic effect judging in COPD.