丙戊酸钠治疗癫痫的个体化差异研究

Observation on the Individual Differences on the Use of Sodium Valproate for Epileptic Seizures

目的：探讨汉族及维吾尔族患者在接受口服丙戊酸钠片治疗癫痫全面强直-阵挛发作过程中存在的个体化差异。方法：选择2010年3月-2014年3月新疆乌鲁木齐市第四人民医院治入院的100例患者,分为汉族患者52例及维吾尔族患者48例两组,接受丙戊酸钠单药治疗进行临床疗效对比。均每天按体重15 mg/kg或每天600-1200 mg,分2-3次口服,始时按5-10 mg/kg,1周后递增,至最大安全剂量为止,记录治疗前后癫痫全面强直-阵挛发作治疗效果。疗效评价：疗效判定标准服药后8周内,癫痫发作减少100%为完全控制,减少75%以上显效,减少50%-75%为有效,减少〈50%为无效。结果：服药8周后汉族组达标率为88.46%,维吾尔族组达标率为70.83%,比较差异有统计学意义（P〈0.05）。结论：相同剂量下丙戊酸钠控制癫痫全面强直--阵挛发作疗效,汉族组疗效优于维吾尔族组。

Objective： To investigate the individual differences of Han and Uygur patients receiving Sodium Valproate Tablet in the treatment of epileptic seizures. Method： There were a total of 100 epileptic patients with generalized tonic-clonic seizure, admitted to the Fourth People＇s Hospital in Urumqi, Xinjiang from March 2010 to March 2014. Among them, 52 were Han Chinese and 48 were Uighurs. The average daily dose of sodium valproate was 15 mg/kg of body weight or 600-1200 mg in total at 2 to 3 times a day. The treatment was initiated with an dose of 5-10 mg/kg of body weight. Seven days later the dose began to increase gradually until it reached the maximum safe dose. The therapeutic effects were evaluated as follows： completely seizure free（100% seizure reduction）, markedly effective（≥ 75% seizure reduction）, effective（50%-75% seizure reduction） and invalid（〈50% seizure reduction）. Result： The treatment was observed effective on 88.46% of the Han group and 70.83% on the Uighur group within 8 weeks. Conclusion： Under the same dose sodium valproate tablet is more curative on Han epileptic patients with generalized tonic-clonic seizure than on the Uighurones.