期刊文献+

Neuropilin-1及其免疫调节机制的研究

下载PDF
导出
摘要 Neuropilin-1(NRP-1)又称为神经纤毛蛋白,是一种非酪氨酸激酶跨膜多功能糖蛋白。其在多种肿瘤组织与免疫细胞上高表达,它作为一个多功能受体,通过独立或依靠其他配体分子的方式,在各种实体肿瘤、血液系统肿瘤及免疫学等方面中发挥重要作用。本文就NRP-1及其配体在肿瘤发生和免疫调节方面的作用机制研究作一综述。
作者 齐凯 杨志刚
出处 《中国医学创新》 CAS 2015年第3期140-143,共4页 Medical Innovation of China
基金 广东省自然科学基金(S2011010005325) 广东医学院科技创新团队(STIF201111)
  • 相关文献

参考文献27

  • 1Takagi S,Tsuji T,Amagai T,et al.Specific cell surface labels in the visual centers of Xenopus laevis tadpole identified using mono-clonal antibodies[J].Dev Biol,1987,122(5):90-100.
  • 2Kitsukawa T,Shimizu M,Sanbo M,et al.Neuropilin-semaphorinⅢ/D-mediated chemorepulsive signals play a crucial role in pe-ripheral nerve projection in mice[J].Neuron,1997,19(5):995-1005.
  • 3Pellet-Many C,Frankel P,Jia H,et al.Neuropilins:structure,function and role in disease[J].Biochem J,2008,411(26):211-226.
  • 4Chen L,Miao W,Tang X,et al.The expression and significance of neuropilin-1(NRP-1)on glioma cell lines and glioma tissues[J].Biomed Nanotechnol,2013,9(4):559-563.
  • 5Solly F,Angelot F,Garand R,et al.CD304 is preferentially expressed on a subset of B-lineage acute lymphoblastic leukemia and represents a novel marker for minimal residual disease detection by flow cytometry[J].Cytometry A,2012,81(1):17-24.
  • 6Lu L,Zhang L,Xiao Z,et al.Neuropilin-1in acute myeloid leukemia:expression and rolein proliferation and migration of leukemia cells[J].Leuk Lymphoma,2008,49(2):331-338.
  • 7Beck B,Driessens G,Goossens S,et al.A vascular niche and a VEGF-Nrp1loop regulate the initiation and stemness of skin tumours[J].Nature,2011,478(7369):399-403.
  • 8Pan Q,Chan thery Y,Liang W C,et al.Blocking neuropilin-1function has an additive effect with anti-vegf to inhibit tumor growth[J].Cancer Cell,2007,11(1):53-56.
  • 9Bruder D,Probst-Kepper M,Westendorf A M,et al.Neuropilin-1:A surface marker of regulatory T cells[J].Eur J Immunol,2004,34(8):623-630.
  • 10Capparuccia L,Tamagnone L.Semaphorin signaling in cancer cells and in cells of the tumor microenvironment—two sides of a coin[J].Cell Sci,2009,122(69):1723-1736.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部