摘要
内质网是机体微环境的重要组成结构和功能单位,内质网内稳态失衡导致的内质网应激成为近年来的一个研究热点。该文主要针对内质网应激在缺血性脑中风中的作用及相关信号通路的研究进展进行综述,特别对内质网应激触发脑中风炎症反应的机制进行了系统的整理和总结,以期为缺血性中风的防治提供新的研究思路。
Endoplasmic reticulum plays a key role in both basic structure formation and function performance of microenviron-ment. Endoplasmic reticulum homeostasis unbalance caused by endoplasmic reticulum stress has become a hot research topic in recent years. This paper focuses on the role of endoplasmic retic-ulum stress in ischemic stroke. Research progress of related sig-naling pathways were reviewed, especially mechanisms through which endoplasmic reticulum stress trigger the inflammatory reac-tion, so as to provide a new research method for prevention of is-chemic stroke.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2015年第1期23-26,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81274133,81303261)
国家科技重大专项(重大新药创制)资助项目(No2012ZX09103201-055)
关键词
缺血性脑中风
神经元损伤
微环境
内质网应激
炎症
相关信号通路
ischemic stroke
neuron injury
microenvironment
endoplasmic reticulum stress
inflammation
related signal path-ways