缺血性脑中风中与内质网应激相关炎症反应研究进展

Research progress of inflammation reaction related to endoplasmic reticulum stress in ischemic endoplasmic reticulum stress

内质网是机体微环境的重要组成结构和功能单位,内质网内稳态失衡导致的内质网应激成为近年来的一个研究热点。该文主要针对内质网应激在缺血性脑中风中的作用及相关信号通路的研究进展进行综述,特别对内质网应激触发脑中风炎症反应的机制进行了系统的整理和总结,以期为缺血性中风的防治提供新的研究思路。

Endoplasmic reticulum plays a key role in both basic structure formation and function performance of microenviron-ment. Endoplasmic reticulum homeostasis unbalance caused by endoplasmic reticulum stress has become a hot research topic in recent years. This paper focuses on the role of endoplasmic retic-ulum stress in ischemic stroke. Research progress of related sig-naling pathways were reviewed, especially mechanisms through＆amp;nbsp;which endoplasmic reticulum stress trigger the inflammatory reac-tion, so as to provide a new research method for prevention of is-chemic stroke.