生长抑素及其类似物在脓毒症患儿中的应用

Application of somatostatin and its analogues in children with sepsis

生长抑素是一种广泛分布于脑组织、胰腺、胃肠道等处的调节肽。临床上，生长抑素及其类似物早已广泛应用于急性胰腺炎的治疗。基于其抑制炎症反应、降低内毒素水平、抑制氧化损伤、增强免疫功能、细胞保护作用、减轻缺血再灌注损伤等作用机制的研究，生长抑素在以上脓毒症的发病机制中可能发挥一定作用，尤其在合并或继发胰腺及胃肠道损伤时作用尤为显著。生长抑素临床应用亦相对安全。

Somatostatin is a regulatory peptide, widely distributed in the brain,pancreas and gastrointes tinal tract. Clinically, somatostatin and its analogues have been widely used in the treatment of diseases such as a cute pancreatitis. Based on studies on the mechanism, such as inhibiting of inflammatory reaction, reducing endo toxin level, inhibiting oxidative damage, enhancing immune function, protecting cells and reducing ischemia reperfusion injury,it may play a cenain role in sepsis, especially in the cornorbidity or secondary to pancreatic and gastrointestinal damage. Somatostatin is relatively safe in clinical aoolication.