补肾活血汤改善冠心病支架置入术后患者勃起功能的临床研究

Bushen Huoxue Decoction improves erectile function of patients with coronary heart disease after percutaneous coronary intervention

目的:观察补肾活血汤对男性冠心病支架置入术后患者勃起功能改善的临床效果。方法:将80例冠心病支架置入术后患者随机分为2组,对照组40例采用冠心病支架置入术后常规西药治疗,治疗组40例在常规西药治疗基础上加服补肾活血汤,连用3个月,观察两组治疗前后国际勃起功能指数5(IIEF-5)的变化。结果:1治疗3个月后治疗组IIEF-5总分为(17.83±4.92)分,高于治疗前的(8.19±2.87)分,IIEF-5各项得分也明显升高,差异均具有显著性(P<0.05);治疗3个月后对照组IIEF-5总分为(12.18±3.69)分,高于治疗前的(7.98±2.96)分,IIEF-5各项得分也明显升高,差异均具有显著性(P<0.05);两组比较,治疗组IIEF-5各项平均得分与总分显著高于对照组(P<0.05)。2治疗组总有效率为72.5%,对照组总有效率为47.5%,差异具有显著性(P<0.05)。3两组在治疗过程中均未出现明显不良反应,无不良事件发生。结论:补肾活血汤可以显著改善冠心病支架置入术后患者勃起功能障碍,提高性生活质量。

Objective： To observe the effectiveness of Bushen Huoxue Decoction in improving the erectile function of male patients with coronary heart disease（ CHD） after percutaneous coronary intervention（ PCI） with stent implantation. Methods： Eighty male CHD patients after PCI with stent implantation were equally assigned to receive conventional Western medicine（ control group）and combination of Western medicine with Bushen Huoxue Decoction（ treatment group）,both for 3 months. Then we compared the pre- and post-medication IIEF-5 scores between the two groups of patients. Results： Compared with pre-medication,the total IIEF-5score was significantly increased after 3 months both in the treatment group（ 8. 19 ± 2. 87 vs 17. 83 ± 4. 92,P 〈 0. 05） and in the control（ 7. 98 ± 2. 96 vs 12. 18 ± 3. 69,P 〈 0. 05）,even higher in the former than in the latter group（ P 〈 0. 05）,and so were the scores on the 5 specific items（ all P 〈 0. 05）. The total effectiveness rate was 72. 5% in the treatment group,significantly higher than47. 5% in the control（ P 〈 0. 05）. No obvious adverse reactions and events were observed during the treatment in either of the groups.Conclusion： Bushen Huoxue Decoction can obviously improve the erectile function and the quality of the sexual life of CHD patients after PCI with stent implantation.