期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

APP/PS1双转基因小鼠阿尔茨海默病模型研究进展 被引量：4

Progress of APP/PS1 double transgenic mice model for Alzheimer＇s disease
原文传递
导出
摘要 人类AD按遗传分为散发性AD及家族性AD;按发病年龄分为早发型AD及晚发型AD.β淀粉样蛋白（Aβ）级联学说主要由家族性AD有关的基因能增加Aβ产生、聚集及Aβ的毒性作用等研究部分组成.家庭性AD大多数病例分别与位于1、14、19和21号染色体基因某些位点突变相关.分别转入人类14、21号染色体的PS1（早老蛋白-1）、淀粉样前体蛋白（APP）基因的APP/PS1双转基因鼠模型可模拟AD的发病及部分病理变化.本文主要对APP/PS1双转基因AD模型鼠遗传学基础、病理学变化及行为学改变等进行探讨.
作者 李芙 姜玉莹 白杨 王鑫 步青云 高堂珂 张忠 薛卫国
机构地区 北京中医药大学针灸推拿学院 北京中医药大学基础医学院
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2015年第1期109-112,共4页 Chinese Journal of Geriatrics
基金 国家自然科学基金资助项目（81273826）
关键词 阿尔茨海默病 小鼠 转基因 Alzheimer disease Mice transgenic
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献27

  • 1Bloom FE, Reilly JF, Redwine JM, et al. Mouse models of human neurodegenerative disorders: requirements for medication development [J]. Arch Neurol, 2005,62: 185-187.
  • 2Dikranian K, Kim J, Stewart FR, et al. Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms., implications for Alzheimerrs disease [J]. Int J Clin Exp Pathol, 2012, 5 482- 495.
  • 3Tortes M, Jimenez S, Sanchez-Varo R, et al. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus[J]. Mol Neurodegener, 2012, 7:59.
  • 4McGowana E, Sandersa S, Iwatsuhob T, et al. Amyioid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes [J].Neurobiol Dis, 1999,6 : 231-244.
  • 5Kurt MA, Davies DC, Kidd M, et al. Neurodegenerative changes associated with beta- amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes [J]. Exp Neurol, 2001, 171: 59-71.
  • 6Gengler S, Hamilton A, Holscher C, et al. Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of alzheimer's disease is impaired in old but not young mice[R]. PLoS One, 2010, 5: 9764.
  • 7Kohman RA, Rhodes JS. Neurogenesis, inflammation and behavior[J]. Brain Behav Immun, 2013, 27: 22-32.
  • 8Casas C, Sergeant N, Itier JM, et al. Massive CA1/ 2 neuronal loss with intraneuronal and N-Terminal truncated A1342 accumulation in a novel Alzheimer transgenic model [J]. Am J Pathol, 2004, 165 : 1289- 1300.
  • 9Flood DG, Lin YG, Lang DM, et al. A transgenic rat model of Alzheimerrs disease with extracellular Abeta deposition[J]. Neurobiol Aging, 2009, 30: 1078-1090.
  • 10Breyhan H, Wirths O, Duan K, et al. APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy [J]. Acta Neuropathol, 2009, 117:677-685.

二级参考文献44

  • 1李爱萍,赵慧,李韶,朴花,孙长凯.不同鼠种在Morris水迷宫学习记忆行为中的种属差异[J].中国行为医学科学,2005,14(1):29-31. 被引量：59
  • 2王跃春.Y型电迷宫在大鼠学习记忆功能测试中的合理运用[J].中国行为医学科学,2005,14(1):69-70. 被引量：60
  • 3孙岩,施佳军,张思仲,唐牟尼,韩海英,郭扬波,马崔,刘协和,李涛.组织蛋白酶D基因C224T多态与散发阿尔茨海默氏病的关联研究[J].遗传,2005,27(2):190-194. 被引量：2
  • 4Goldgaber D, Lerman M h McBride O W, Saffiotti U, Gajdusek D C. Characterization and chromosomal location of a cDNA encoding brain amyloid of Alzhaimer's disease. Science, 1987,235 (4791):877-880.
  • 5Kang J, Lemaire H, Unterbeck A, Salbaum J M, Masters C L,Grzeschik K, Multhaup G, Beyreuther K, Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature, 1987, 325 (6106):733-736.
  • 6St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G,Pericak-Vance M, Foncin J F, Montesi M, Bruni A, Sorbi S, Rainero I, Pinessi L, Pollen D, Polinsky R, Nee L, Kennedy J, Macciardi F, Rogaeva E, Liang Y, Alexandrova N, Lukiw W, Schlumpf K,Tanzi R, Tsuda T, Farrer L, Cantu J M, Duara R, Amaducci L, Bergamini L, Gusella J, Roses A, Crapper McLachlan D. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nature Genetic, 1992, 2(4):330-334.
  • 7Nakano Y, Kondoh G, Kudo T, Imaizumi K, Kato M, Miyazaki JI, Tohyama M, Takeda J, Kakeda M. Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1‘knock-in’ mice. European Joumal of Neuroscience 1999. 11(7)：2577-2581.
  • 8McGowan E, Sander S, Iwantsubo T, Takeuchi A, Saidou T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dicksce D, Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein andmutant presenilinl transgenes.Neurobiology of Disease, 1999. 6(4):231-244.
  • 9Gordon MN, King DL, Diamond DM et al. Correlation between cognitive deficits and Aβ deposits in transgenic APP/PS1 mice. Neurobiol Aging, 2001 ;22:377 - 386
  • 10Cummings B, Pike C J, Shankle R et al. Beta-amyloid deposition, and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol Aging, 1996 ; 17:921 - 933

共引文献43

同被引文献39

  • 1王之莹,李婷婷,于文杰,陈爱亮.一种适用于乳制品基因组DNA快速提取方法的研究[J].食品安全质量检测学报,2020,11(1):134-139. 被引量：2
  • 2魏刚,方永奇,柯雪红,林双峰,吴启端.石菖蒲开窍醒神物质基础的药学系列研究[J].中国中医药信息杂志,2005,12(8):51-53. 被引量：31
  • 3卓祥龙,李世德.骨肉瘤基因组DNA的提取及部分酶切分析[J].医学文选,2005,24(5):660-663. 被引量：2
  • 4刘英,高璐,马丽香,林芮禾,刘惠婷,姚君如,陈祖林,李瑞锡,彭裕文.APP/PS1双转基因小鼠大脑皮质老年斑的病变对其学习记忆能力的影响[J].神经解剖学杂志,2007,23(3):225-231. 被引量：10
  • 5Robakis NK. Mechanisms of FAD neurodegeneration may be independent of A[3[ J]. Neumbiol Aging,2011,32(3) :372 -379.
  • 6Takeda S, Sato N, Morishita R. Systemic inflammation, blood - brain barrier vulnerability and cognitive/non - cognitive symptoms in Alzhe- imer disease: relevance to pathogenesis and therapy [ J ]. Front Aging Neurosci ,2014,6 : 171.
  • 7Delrieu J, Ousset PJ, Cailland C, et al. Clinical trials in Alzheimer' s disease' : immunotherapy approaches [ J ]. J Neurochem, 2012, 120 (1) :186 -193.
  • 8Kanekiyo T, Bu G. The low - density lipoprotein receptor - related protein 1 and amyloid- [3 clearance in Alzheimer disease[ J]. Front Aging Neurosci ,2014,6:93.
  • 9Li X, Guo F, Zhang Q, et al. Electreacupuneture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice [ J]. BMC Complement Altern Med,2014,14:37.
  • 10Sagare AP, Deane R, Zlokovic BV. Low - density lipoprotein receptor -related protein l:a physiological A13 homeostatic mechanism with multiple therapeutic opportunities [ J ]. Pharmacol Ther, 2013, 136 (1) :94 -105.

引证文献4

二级引证文献11

中华老年医学杂志
2015年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部