fMRI分析非临床抑郁大学生杏仁核及海马静息态功能连接的改变

fMRI analysis on the resting-state functional connectivity of amygdala and hippocampus in college students with non-clinical depressive symptoms

目的分析非临床抑郁症状(nCDSs)被试杏仁核及海马静息态功能连接的特征。方法采用贝克抑郁量表(BDI)对1105名大学生进行抑郁症状评估,对其中17例符合nCDSs的被试(nCDSs组)及20名对照组被试进行静息态fMRI检查。以双侧杏仁核及海马为种子点,分别对全脑进行基于体素的rsFC分析,比较两组间的rsFC差异,并与nCDSs者的BDI评分进行相关分析。结果与对照组比较,nCDSs组以双侧杏仁核为种子点,右侧眶额叶内侧面rsFC均增强;以左侧海马为种子点,右侧枕叶舌回、双侧额叶直回及左侧楔前叶rsFC增强;以右侧海马为种子点,右侧小脑后叶、右侧枕叶舌回、双侧额叶直回、左侧楔前叶及左侧中央旁小叶rsFC增强。nCDSs被试双侧杏仁核及海马rsFC改变与BDI评分无相关性(P>0.05)。结论 nCDSs被试杏仁核及海马的rsFC存在异常,可能在nCDSs的病理机制中发挥重要作用。

Objective To analyze the features of resting-state functional connectivity（rsFC）of the amygdala and hippocampus in non-clinical depressive symptoms（nCDSs）subjects.Methods Beck Depression Inventory（BDI）was used to define the depressive severity in 1105 college students,and then 17 subjects with nCDSs（nCDSs group）and 20 health controls（control group）were enrolled and underwent fMRI.Bilateral amygdala and hippocampus were used as the seed regions to perform voxel-based rsFC analysis.The rsFC alteration between the two groups was investigated,and then the correlation between the BDI scores and rsFC values in nCDSs subjects was analyzed.Results Compared with control group,nCDSs group exhibited increased rsFCs in the right medial orbital frontal lobe when bilateral amygdala as seed regions,and increased rsFCs in the right lingual gyrus,bilateral rectus and left precuneus when left hippocampus as seed region,as well as increased rsFC in the right posterior cerebellum lobe,right lingual gyrus,bilateral rectus,left precuneus and left paracentral lobule when right hippocampus as seed region.There was no significant correlation between the altered rsFCs values and BDI scores in nCDSs subjects（P〉0.05）.Conclusion The altered rsFCs of the amygdala and hippocampus may be biomarkers that are related to the pathophysiology of nCDSs.