益气活血解毒化痰方治疗慢性病毒性乙型肝炎肝纤维化临床研究

Clinical Research on Yiqi Huoxue Jiedu Huatan Fang Treatment of Liver Fibrosis Induced by Chronic Hepatitis B

目的:观察益气活血解毒化痰方治疗慢性病毒性乙型肝炎肝纤维化的临床疗效。方法:86例慢性病毒性乙型肝炎肝纤维化患者随机平均分为中药组和常规组。对照组按照临床诊疗指南给予常规治疗,中药组在此基础上给予益气活血解毒化痰方治疗,3个月为1个疗程,两组均治疗2个疗程。比较两组患者中医证候积分、症状体征评分、血清肝纤维化指标、超声影像学指标和S指数(一种肝纤维化非创伤性诊断模型),以评价临床综合疗效。结果:治疗后,两组患者证候积分较治疗前有所改善(P<0.05),且中药组证候积分显著低于常规组(P<0.05);两组血清肝纤维化指标、S指数评分、门静脉直径、脾肿指数均较治疗前明显改善(P<0.05);中药组患者有效率明显高于常规组(P<0.05)。结论:益气活血解毒化痰方治疗慢性病毒性乙型肝炎肝纤维化临床疗效显著。

Objective ： To study the clinical effect of Yiqi Huoxue Jiedu Huatan Fang treatment of liver fibrosis induced by chronic hepati- tis B. Methods：86 patients Patients with chronic viral hepatitis B liver fibrosis were randomly divided into Chinese medicine group and routine group, each of 43 cases. Both groups received conventional treatment, and Chinese medicine group was additionally administered Yiqi Huoxue Jiedu Hnatan Fang. 3 months as one course of treatment,totally 2 courses. Evaluated the clinic comprehensive effects by means of observing TCM syndrome score, clinical symptoms and signs, serological indices of liver fibrosis, S index, and ultrasonic ima- ging. Results ： After treatment, both groups were significantly improved in TCM syndromes scores （ P 〈 0.05 ） , and chinese medicine group was significantly lower than the normal group（ P 〈0.05 ）. Both groups could significantly improve the serological indices of liver fibrosis, S index, the trunk diameter of hepatic portal vein, and the spleen index（ P 〈 0.05 ）. Clinical efficacy of Chinese medicine group was superior to the routine group（ P 〈 0.05 ）. Conclusion ： Yiqi Huoxue Jiedu Huatan Fang treatment of liver fibrosis induced by chronic hepatitis B has obvious effect.