高血压合并糖尿病患者同型半胱胺酸与超敏C反应蛋白水平分析及健康教育对策

Homocysteine and Hypersensitive C-reactive Protein of Hypertensive Patients with Diabetes and Its Health Education

目的调查炼化社区原发性高血压及高血压合并糖尿病患者血浆同型半胱氨酸、超敏C反应蛋白水平,探讨相关的健康教育对策。方法选取炼化社区已纳入我院慢病管理科的高血压患者为病例组,以本社区健康人群为健康对照组,分析高血压各亚组、高血压合并糖尿病组与健康对照组之间的血浆同型半胱胺酸、超敏C反应蛋白值的差异。结果高血压各亚组间的血浆同型半胱胺酸、超敏C反应蛋白水平、高检出率及同型半胱酸的边缘升高率均随着高血压级别升高逐渐增高;高血压合并糖尿病患者的血浆同型半胱胺酸和超敏C反应蛋白水平、高检出率及同型半胱胺酸的边缘升高率均高于单纯性高血压组,单纯性高血压组高于健康对照组,差异有统计学意义(P<0.01)。结论对重点人群定期进行血浆同型半胱胺酸、超敏C反应蛋白动态水平的监测,动态评估病情发生发展的严重程度,制定健康教育对策,以做到早发现、早预防,减少心脑血管不良事件的发生,降低脑卒中的发生与发展。

Objective To investigate the homocysteine（HCY） and Hypersensitive c-reactive protein（hs-CRP） of essential hypertension（EH） patients and hypertensive patients with diabetes and to discuss its corresponding health education. Methods Hypertensive patients were involved into experiment group and health objects into control group. The difference of HCY and hs-CRP was recorded. Results There was positive relationship among HCY, hs-CRP, detection rate, marginal increase of hs-CRP and the high blood pressure. In hypertensive patients with diabetes group, their HCY, hs-CRP and detection rate were higher and there was significant marginal increase of hs-CRP when compared with those in hypertensive patient group. HCY, hs-CRP, detection rate and marginal increase were the lowest in control group. Conclusion Regular detection of HCY and monitoring of hs-CRP of key population contribute to observing the development of hypertension and corresponding health education helps to decrease the incidence of stroke.