摘要
目的通过静息态功能磁共振成像(rs-f MRI)技术对脑白质疏松(LA)轻度认知障碍(MCI)患者脑默认网络进行分析。方法LA患者31例,临床痴呆评分(CDR)0.5;年龄、性别和受教育程度匹配的正常对照组27人,CDR为0。对入组人群进行rs-f MRI数据采集。使用SPM5软件进行分析处理,使用f MRI工具盒对预处理后的数据进行独立成分分析(ICA),组间差异进行双样本t检验。结果静息状态下,对照组默认网络包括扣带回后部/楔前叶,双侧额叶内侧,双侧颞中回,双侧顶下回、角回,双侧海马。MCI组默认网络激活区域同对照组一致;同对照组相比,MCI患者扣带回前部/左侧额叶内侧、右侧海马旁回/钩回、右侧颞下回、左侧额叶深部白质/尾状核头部激活减低,左侧尾状核/扣带回前部、左侧额叶、左侧颞上回/顶下回的激活升高。结论LA患者静息状态默认网络活动异常,可能与认知障碍的发生有关。
Objective To study the default mode network(DMN) of mild cognitive impairment(MCI) related to leukoaraiosis(LA)with resting-state functional magnetic resonance imaging(rs-f MRI). Methods 31 LA patients(Clinical Dementia Rating of 0.5) and 27 normal controls(Clinical Dementia Rating of 0, and matched in age, gender and lever of education) were scanned with the rs-f MRI. The data was analyzed with SPM5 software, using independent component analysis. The differences between the both groups were compared with two-sample t-test. Results The DMN during resting-state of normal controls was posterior cingulate cortex/precuneus, bilateral medial frontal cortex, bilateral middle temporal gyrus, bilateral inferior parietal gyrus, angular gyrus, bilateral hippocampus. The DMN of MCI group was consistent with the normal controls, but the activation decreased in anterior cingulate cortex/left medial frontal lobe, right parahippcampus/uncus, right inferior temporal gyrus, left deep frontal white matter/head of caudate nucleus; and increased in the left caudate nucleus/anterior cingulate cortex, left frontal lobe, and left superior temporal gyrus/inferior parietal gyrus. Conclusion Activation of resting-state functional network is disorder in LA, which may relate to cognitive impairment.
出处
《中国康复理论与实践》
CSCD
北大核心
2014年第12期1133-1139,共7页
Chinese Journal of Rehabilitation Theory and Practice
基金
北京师范大学认知神经科学与学习国家重点实验室办公室开放课题
国家自然科学基金项目(No.81371201
No.31171073)
国家社科基金重大项目(No.11&ZD186)
国家科技支撑计划项目(No.2013BAI09B03)
北京市卫生局高层次人才基金(No.11420076)
北京市教委课题(No.KM20130025019)
“973”青年科学家项目(No.2013CB837300)
北京脑重大疾病研究院项目(No.BIBD-PXM2013_014226_07_000084)
关键词
脑白质疏松
轻度认知障碍
静息态功能磁共振
默认网络
leukoaraiosis
mild cognitive impairment
resting-state functional magnetic resonance imaging
default mode network