纤维素基磁性微胶囊的制备及其优化条件研究

Preparation and Study on Optimization of Cellulose based Magnetic Microcapsule

磁性粒子具有优异的磁导向性可被用于药物缓释系统而受到大家广泛关注.人们期待用具有特殊功能的其他纳米粒子和磁性粒子结合,赋予磁性粒子更多的功能.文章将天然高分子材料羧甲基纤维素钠(CMC)和壳聚糖(CS)组装包覆在具有超顺磁性的Fe3O4纳米微球外层成功制备出纤维素基磁性微胶囊,并研究了CMC的取代度对磁性微胶囊的形貌及磁性能的影响.电子显微镜观察结果表明其颗粒成比较规则的球形、分散性比较好且具有超顺磁性;CMC的取代度(DS)大小对磁性微胶囊的形貌以及磁性能存在一定的影响,当DS在1.05左右时得到的微胶囊分散性最好,磁响应范围最广、比饱和磁化强度也最大.

In recent years, because it has special magnetic orientation and excellent biocompatibility, the applied research in the biological field of the superparamagnetic nanopaticles causes people＇s attention increasingly. It is expected that some nanoparticles have special functions integrate with magnetic particles, which provide the magnetic particles with more functions. The main content of the article was the synthesis and characterization of the magnetic bifunctional nanocompasites and their application in biology, detail were as follows：Fe3 04 magnetic particles coated with CS are prepared by the method of coordination polymerization. The results of SEM show that the particles are regular sphere and have goof dispersion. Also, the particles show superparamagnetic under the room temperature. With the method of LbL self-assambly, CS and CMC with different DS are coated on the surface of Fe3 04 magnetic particles alternately. The results show that when the CMC with DS 1. 05 acts as shell material, the microspheres have the best dispersion and the maximum saturation magnetization and magnetic resoonse range.