成纤维细胞生长因子及其受体抑制剂的研究进展

Research Progress of Fibroblast Growth Factors(FGFs) and FGFR Inhibitors

成纤维细胞生长因子受体(FGFRs)是受体酪氨酸激酶(RTKs)超家族的一员,它可以与成纤维细胞生长因子(FGFs)结合,引发靶细胞的多种反应,同时参与许多生物过程,如细胞增殖、抗凋亡及血管生成等,发挥其生理功能。FGFRs分别在癌细胞和内皮细胞中参与肿瘤的发生和血管的生成,因此,FGFRs-靶向药物会产生直接或间接的抗癌作用。简单介绍了FGFs及FGFRs,重点对FGFR抑制剂的研究进展进行了综述。

Fibroblast growth factors receptor（FGFRs）is the member of receptor tyrosine kinases（RTKs）.It binds with fibroblast growth factors（FGFs）to trigger a variety of responses in target cells,and participates in many cellular processes,such as proliferation,anti-apoptosis and angiogenesis,to develop its physiological function.FGFRs-Targeted drugs exert direct as well as indirect anticancer effects,because FGFRs is involved in tumorigenesis and vasculogenesis in cancer cells and endothelial cells,respectively.FGFs and FGFRs are introduced briefly in this paper.And the research progress of FGFR inhibitors are summarized.