FGFR1、FGFR3和Pokemon在膀胱癌中的表达及相关性研究

Study on Protein Expression and Clinical Correlations of FGFR1,FGFR3 and Pokemon in Bladder Cancer

目的通过观察FGFR1、FGFR3和Pokemon在膀胱癌组织的表达情况,探讨它们在膀胱癌发生、发展中的作用。方法采用免疫组化检测296例膀胱癌和48例正常膀胱组织中FGFR1、FGFR3和Pokemon蛋白的表达情况。结果 1)FGFR1在膀胱癌不同病理分期、分级及初发复发的表达率为:Ta-T1期7.5%,T2-T4期18.1%(p<0.01);低级别2.8%,低-高级别11.9%(p<0.05),高级别14.3%的(p<0.01);初发表达6.8%,复发表达率17.1%(p<0.01)。2)FGFR3在膀胱癌不同病理分期、分级的表达率为:Ta-T1期68.1%,T2-T4期35.0%(p<0.01));低级别75.0%,低-高级别60.3%(p<0.05),高级别44.9%(p<0.01)。3)Pokemon在膀胱癌不同病理分级及初发复发的表达率为:低级别47.2%,低-高级别66.7%(p<0.01),高级别80.6%(p<0.01);初发59.2%,复发80.0%(p<0.01)。结论 FGFR1在膀胱癌中的表达与病理分级、分期成正相关,复发表达明显高于初发;Pokemon在膀胱尿路上皮癌中的表达与病理分级成正相关,复发表达也明显高于初发,表明它们可能主要参与膀胱癌发展及转移等过程。FGFR3在膀胱癌中的表达与病理分级、分期成负相关,表明它可能在膀胱癌发展早期及低级别肿瘤发展中发挥着重要作用。

Objective By the study on protein expression of FGFR1 ,FGFR3 and Pokemon in bladder cancer,to identify their function in the development role of bladder cancer.Methods Immunohistochemistry was used to detect FGFR1 ,FGFR3 and Pokemon protein in 296 cases of bladder cancer and 48 cases of normal bladder tissue.Results 1 ）FGFR1 bladder cancer in different pathological stage,grade and onset recurrent expression was：Ta-T1 7. 5%,T2-T4 1 8. 1% （p〈0. 01 ）;low level 2. 8%,low-high level 1 1 . 9% （p〈0. 05）,high-level 1 4.3% （p〈0. 01 ）;early publication 6.8%,the recurrence expres-sion 1 7. 1% （p〈0. 01 ）.2 ）FGFR3 in various pathological staging of bladder cancer,grading expression was：Ta-T1 68. 1%,T2-T4 35. 0% （p〈0. 01 ）;low-level 75. 0% ,low-High level 60. 3% （p〈0. 05 ）,high level 44. 9% （p〈0. 01 ）.3.Pokemon in different pathological grading of bladder cancer recurrence and the onset of expression was：47. 2%low-level,low-High level 66. 7%（p〈0. 01 ）,high-level 80. 6%（p〈0. 01 ）;initial issuance 59. 2%,relapse 80.0%（p〈0. 01 ）.Conclusion FGFR1 expression and tumor grade in bladder cancer,staging a positive correlation,relapse was signifi-cantly higher than the initial issuance;Pokemon expression was positively correlated with tumor grade,recurrence expression was also significantly higher than the onset of bladder urothelial carcinoma,suggesting that they may be mainly involved in the process of developing bladder cancer and metastasis.FGFR3 expression and tumor grade,stage a negative correlation in bladder cancer,suggesting that it may develop in the early stage of bladder cancer and low-grade tumor development plays an important role.