肠道菌群与2型糖尿病相关性的研究进展

The relationship between gut microbiota and type 2 diabetes mellitus: research progress

目的糖尿病是一种常见的代谢性疾病,发病率高,易引起严重的微血管、大血管并发症,造成多重器官损伤;缺乏有效的治疗手段,患者生存质量普遍偏低,致残率、致死率走高;发病机制异常复杂,目前仍未能完全阐明。近年来,大量报道显示,肠道菌群作为人体不可分割的部分,参与了宿主的健康维持和疾病发生,与2型糖尿病的发生、发展有着直接的关系。本文就肠道菌群与2型糖尿病的相关性研究进展进行简要综述,为肠道菌群及2型糖尿病的相关研究提供参考。

Objective Diabetes mellitus is a common metabolic disorder with a high morbidity and high risk of de- veloping microvascular and macrovascular complications which cause great damages to multiple human organs. Due to the lack of any effective treatment, patients with diabetes usually have a rather low quality of life, and the disa- bility and death rates in them are increasing. The pathogenesis of diabetes has not been inadequately understood since it is extremely complicate. Recently, a plenty of researches suggest that gut microbiota, as an inseparable part of human body, involves in maintaining human health and developing diseases, and directly relates to the oc- currence and development of type 2 diabetes. This paper reviews the relationship between gut microbiota and type 2 diabetes to provides references for the studies of gut microbiota and type 2 diabetes.