microRNA在非酒精性脂肪性肝病中的作用

Research progress on the role of miRNAs in the regulation for NAFLD

microRNA(miRNA)是一类长度约为22个核苷酸的内源性非编码小分子RNA,通过影响靶mRNA的稳定性或抑制其翻译,从而对基因进行转录后水平的调控。研究发现,一些miRNA在非酒精性脂肪性肝病患者中出现差异性表达,这些差异性表达有多种功能,包括调节脂质和糖代谢,参与折叠蛋白反应、内质网应激、氧化应激、细胞分化、炎性反应及细胞凋亡。此文就miRNA在非酒精性脂肪性肝病病程中的潜在重要作用进行概述。

MicroRNAs （miRNAs） are endogenous, -22 nucleotide, small non-coding RNAs which typically regulate gene expression after transcription by affecting the stability or translation of targeted mRNA. Studies have found that some of miRNAs are expressed abnormaly in patients with nonalcoholic fatty liver disease （NAFLD）. The differential expression profiles of miRNA have a variety of biological activities and are in- volved in the regulation of lipid and glucose metabolism, protein folding reaction, endoplasmic reticulum stress, oxidative stress, cell differentiation, inflammation and apoptosis. This review describes the potential functions ofmiRNAs during NAFLD development.