美洛西林钠舒巴坦钠致急性喉水肿及过敏性休克1例

One case of acute laryngeal edema and allergic shock caused by mezlocillin sodium and sulbactam sodium

1例55岁男性患者,既往无青霉素过敏史,因"急性扁桃体炎"给予美洛西林钠舒巴坦钠(5 g,bid,ivgtt),用药15 min后,患者出现胸闷不适,未予重视。再次输注该药约5 min后,患者出现严重过敏反应,表现为呼吸困难,血压测不出,心跳呼吸骤停,立即停药,给予胸外按压,气管插管见喉水肿,呼吸机辅助呼吸。先后给予肾上腺素、地塞米松、多巴胺等药物治疗,10 min后患者心跳、自主呼吸恢复,转入急诊监护病房继续治疗。

One 55-year-old male patient with no penicillin allergy history received mezlocillin sodium and sulbactam sodium （5 g, bid, ivgtt） because of acute tonsillitis. About 15 minutes later, the patient complained of chest discomfort, but received no attention. Then the patient received the same lfuid infusion, 5 minutes later, he developed the serious allergic reaction, characterized by dyspnea, cardiopulmonary arrest, and the blood pressure couldn＇t be measured. The drugs were stopped immediately, and the patient was given chest compressions, endotracheal intubation, assisted mechanical ventilator, drug treatment such as epinephrine, dexamethasone, dopamine, etc. Ten minutes after the symptomatic treatment, the patient＇s heart beat and spontaneous breathing recovered, then he was transferred to emergency care unit for continuous treatment.