摘要
目的:研究奥氮平、利培酮、阿立哌唑、喹硫平对202例精神分裂症患者QTc影响的性别差异。方法:入组奥氮平组55例,利培酮组51例,阿立哌唑组58例,喹硫平组38例,每例患者均进行心电图检查,同时计算QTc值。结果:四种非典型抗精神病药物组之间QTc间期存在明显差异,方差分析表明喹硫平组的平均QTc间期显著长于利培酮、阿立哌唑组,奥氮平组的平均QTc间期显著长于利培酮组。对女性患者而言,四种抗精神病药物组QTc间期的差异有统计学意义(P<0.05)。然而,男性患者之间比较差异无统计学意义(P>0.05)。在奥氮平组,女性患者的平均QTc要显著长于男性患者(P<0.05),而在其他组则没有明显差异(P>0.05)。结论:与利培酮和阿立哌唑相比,奥氮平、喹硫平对QTc间期的影响更为明显,在女性患者中这种影响更为明显。
Objective： To study sex differences in the effect of olanzapine（OLZ）,risperidone（RIS）,aripiprazole（ARP）,or quetiapine（QTP） on mean corrected QT（QTc） intervals among 202 patients with schizophrenia.Method： Subjects were patients with schizophrenia who were treated with either OLZ（n=55）,RIS（n=51）,ARP（n=58）,or QTP（n=38）. Electrocardiographic measurements were conducted,and the QT interval was corrected using Bazett＇s correction formula. Result： The mean QTc interval of the QTP group was significantly longer than that of the RIS group（P〈0.05） or ARP group（P〈0.05）. The mean QTc interval of the OLZ group was also significantly longer than that of the RIS group（P〈0.05）.In female participants,the difference in the mean QTc interval among the four second-generation antipsychotic groups was statistically significant（P〈0.05）,whereas in male patients,there was no significant difference in the mean QTc interval among the four SGA groups（P〉0.05）. Post hoc analyses show that sex differences in QTc interval were observed only in OLZ treatment group（P〈0.05）.Conclusion： The OLZ and QTP treatment had a greater impact on the QTc interval compared with RIS or ARP. These effects are evident especially in female participants.
出处
《中外医学研究》
2014年第36期14-15,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
