探讨口服米非司酮配合乳酸依沙吖啶对中晚期妊娠引产的临床治疗效果

Investigate the Clinical Effectiveness of Mifepristone and and Ethacridine Lactate in Terminating of Second and Later Trimester Pregnancy

目的:评价口服米非司酮联合乳酸依沙吖啶在中晚期妊娠引产中的临床疗效及安全性。方法:选取2013年7月-2014年7月笔者所在医院收治的进行中晚期妊娠引产的孕妇88例,随机分为观察组和对照组,其中观察组44例,采用口服米非司酮联合羊膜腔内注射乳酸依沙吖啶治疗,对照组44例,采用羊膜腔注射乳酸依沙吖啶治疗。观察并比较两组患者宫缩开始时间、胎儿娩出时间、胎盘娩出时间、总引产时间、产后24 h出血量及并发症的发生情况。结果:观察组宫缩开始时间为(15.14±2.80)h,胎儿娩出时间为(10.42±3.17)h,胎盘娩出时间为(4.61±1.30)h,总引产时间为(29.95±4.75)h,对照组宫缩开始时间为(21.74±3.37)h,胎儿娩出时间为(14.55±1.91)h,胎盘娩出时间为(5.90±1.61)h,总引产时间为(41.91±5.63)h,两组患者宫缩开始时间、胎儿娩出时间、胎盘娩出时间及总引产时间比较差异有统计学意义(P<0.05)。观察组产后24 h出血量明显低于对照组,差异有统计学意义(P<0.05);观察组有3例患者发生胎盘残留,1例患者发生阴道出血(≥200 ml),并发症的发生率为9.09%,对照组有5例患者发生胎盘残留,2例患者发生阴道出血,1例患者发生软产道损伤,并发症的发生率为18.18%。两组患者并发症的发生率比较差异有统计学意义(P<0.05)。结论:口服米非司酮联合羊膜腔内注射乳酸依沙吖啶治疗中晚期妊娠引产临床疗效好,并发症发生率低,值得在临床上予以推广。

Objective：To investigate the clinical effectiveness of Mifepristone and Ethacridine Lactate in terminating of second and later trimester pregnancy.Method：88 patients were selected from July 2013 to July 2014 who were divided randomly into observation group（44 cases） and control group（44 cases）,and the observation group was treated with Mifepristone and amniotic cavity injection of Ethacridine Lactate,the control group was treated with amniotic cavity injection of Ethacridine Lactate.The contractions start time,fetal childbirth time,placenta time,total induced labor time,24 h blood loss and complications after postpartum were observed.Result：In the observation group,contractions start time was（15.14 ±2.80）h,fetal childbirth time was（10.42±3.17）h,the placenta time was（4.61±1.30）h,the total induced labor time was（29.95±4.75）h,and in the control group,contractions start time was（21.74±3.37）h,fetal childbirth time was（14.55±1.91）h,the placenta time was（5.90±1.61）h,total induced labor time for（41.91±5.63）h,The differences of two groups were statistically significant with contractions start time,fetal childbirth time,the placenta time and total induced labor time（P〈0.05）.24 h blood loss after postpartum in the observation group was obviously lower than the control group,the difference was statistically significant（P〈0.05）.In the observation group,there were 3 patients with placenta residue,1 case occurred vaginal bleeding（ ≥ 200 ml）,the incidence of complications was 9.09%,in the control group,there were 5 patients with placenta residue,2 cases occurred vaginal bleeding,soft birth canal of 1 patient was injury,and the incidence of complications was 18.18%.the difference was statistically significant at the incidence of complications in the two groups（P〈0.05）.Conclusion：The clinical effectiveness of Mifepristone and Ethacridine Lactate in terminating of second and later trimester pregnancy is better,low complication rate,worthy of popularization in clinical.