阿立哌唑联合米氮平治疗精神分裂症的疗效及对患者认知功能和生活质量的影响

The curative effect of aripiprazole combination with mirtazapine for patients with schizophrenia

目的探讨阿立哌唑联合米氮平治疗精神分裂症的疗效及对患者认知功能和生活质量的影响。方法 110例符合纳入标准的精神分裂症患者随机分为2组,每组各55例。对照组给予阿立哌唑治疗,观察组在对照组的基础上联合使用米氮平治疗。治疗后比较2组疗效及对患者认知功能和生活质量的影响。结果治疗后,观察组有效率90.9%,明显高于对照组的76.4%(P<0.05)。观察组连线测验A、数字广度、数字符号及视觉再生等指标较对照组改善更明显,差异均有统计学意义(P均<0.05)。生活质量方面,观察组躯体功能、躯体角色、总的健康、活力、社会功能和心理卫生评分均高于对照组(P均<0.05),而机体疼痛和情绪角色方面2组比较无显著差异(P均>0.05)。结论阿立哌唑联合米氮平治疗精神分裂症的疗效可靠,可提高有效率,改善患者认知功能及生活质量,值得临床进一步研究和推广。

Objective To investigate the curative effect of aripiprazole combination with mirtazapine for patients with schizophrenia. Methods One hundred and ten patients with schizophrenia were randomly divided into the control group （n=55 ,treated by aripiprazole） and observation group （n=55 ,treated by aripiprazole combination with mirtazapine ）. The curative effect ,cognitive function and life quality of two groups were compared.Results The effective rate was 90.9% in the observa-tion group and 76.4% in the control group ;the trail making test A ,digital span ,digital symbol ,visual reproduction ,somatic function ,somatic role ,general health status ,vitality ,social function and mental health of observation group were better than these of control group ;the bodily pain and emotional role of two groups had no statistical difference. Conclusion Aripiprazole combined with mirtazapine have better curative effect for patients with schizophrenia and can improve the cognitive function and life quality of patients ,which is worthy of applicationl.