玻璃体注射抗VEGF药物与持续性眼压升高相关性的Meta分析

Meta-analysis of correlation between intravitreal injection of anti-VEGF drugs and persistent elevation of intraocular pressure

目的系统评价玻璃体注射抗VEGF药物后持续性眼压升高情况。方法计算机检索Pubmed数据库、EMbase、中国生物医学文献数据库、中文科技期刊全文数据库,纳入玻璃体注射抗VEGF药物发生持续性眼压升高的临床研究。由两名评价者独立选择试验研究、提取资料和方法学质量评估。研究数据的统计学分析采用RevMan 5.0软件分析。结果最终纳入9篇临床研究,其中5篇文献指出了抗VEGF药物的眼内注射与术后眼内压持续性升高相关,4篇文献认为无此相关性,这4篇文献中其中3篇有对照组统计分析,MINORS平均得分为22.7（22～24）,其他6篇MINORS平均得分为11.5（11～13）。对有对照组统计分析的3篇研究进行资料合并后进行了Meta分析显示：抗VEGF药物注射与长期眼压升高无明显相关性（P=0.55）。结论抗VEGF药物的眼内注射与术后眼内压持续性升高无必然联系。

Objective To evaluate systematically the correlation beteween persistent intraocular pressure and intravitreal injection of anti-VEGF drugs. Methods To search the Pubmed database, EMbase, Chinese Biomedical Literature Database, Chinese Science and Technology Periodicals Database, and to include all clinical studies about the persistent elevation of intraocular pressure after intravitreal injection of anti-VEGF drugs. Two independent reviewers select experimental studies, extract data and assess methodological quality. RevMan5.0 software was used in statistical analysis of research data. Results Nine clinical studies were selected. There were five among nine literature to point out the positive correlation of anti-VEGF drugs injection and postoperatively sustained ocular hypertention, and there were four among nine literature to point out no such correlation. Three of four documents had control group statistical analysis, the average score of MINORS was 22.7 （22 to 24）. Other six documents average score of MINORS was 11.5 （I I to 13）. After these three studies were conducted Meta-analysis of the combined data, and concluded that intraocular injections of anti-VEGF drugs and postoperative persistent elevated intraocular pressure was no significant correlation. Conclusion Intraocular injection of anti-VEGF drugs has not necessarily linked with postoperative persistent elevated intraocular.