干燥综合征伴周围神经病变临床研究

Peripheral neuropathy in sjgren's syndrome:a retrospective report of one case with literature review

目的探讨干燥综合征伴周围神经病的机制、临床表现及治疗措施。方法对1例以周围神经病变为首发症状的干燥综合征患者的诊疗经过进行分析。结果本例患者以右侧眼睑闭合不全发病,临床免疫学检测抗核抗体胞浆型1∶320、抗SSA/Ro60抗体阳性、抗SSB抗体阳性,唇腺活检提示(下唇)间质慢性炎,可见淋巴细胞灶。经糖皮质激素、营养周围神经等药物治疗后症状改善。结论干燥综合征伴周围神经系统损害的患者,早期临床症状常不明显且缺乏典型性,应结合血清学及唇腺病理学等检查,有助于早期诊断,避免漏诊误诊。

Objective To investigate the mechanism ,clinical manifestations and therapeutic options of sj gren＇s syndrome patient with peripheral neuropathy.Methods One sj gren＇s syndrome patient with peripheral neuropathy was retrospectively re‐viewed.Results This patient was finally diagnosed as sj gren＇s syndrome with neurologic manifestation of lagophthalmos on the right. Clinical immunology results showed that anti‐SSA/Ro60 and anti‐SSB antibody were positive ,otherwise ,antinuclear cy‐toplasmic antibodies in type‐1 was 320. Labial salivary gland biopsy suggested that this was typically chronic inflammation in interstitial with lymphocytic infiltration. The clinical symptoms were alleviated by glucocorticoid and peripheral nerve nutrition‐al medicine treatments.Conclusion In order to avoid misdiagnosis and early detection for sj ？gren＇s syndrome‐suspicious pa‐tients ,serological examination and labial salivary gland biopsy were recommended.