神经节苷脂治疗新生儿缺氧缺血性脑病的有效性及安全性

Efficiency and safety of gangliosides in the treatment of neonatal hypoxic-ischemic encephalopathy

目的评价神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的有效性及安全性。方法随机抽取2012-12—2013-12我院住院治疗的54例新生儿缺氧缺血性脑病患者作为研究对象,按照随机双盲对照原则分为对照组和观察组,对照组主要采取综合治疗,观察组在综合治疗的基础上以神经节苷脂治疗,治疗后观察2组患者新生儿行为神经评分,并比较2组患者NSE、S100B水平。结果 2组患者NBNA评分在治疗第10天逐渐出现差异,观察组患者较对照组NBNA评分高,治疗第28天2组NBNA评分差异增大;观察组患者较对照组血清NSE、S100B水平高,2组比较差异有统计学意义(P<0.05)。结论神经节苷脂治疗HIE临床效果良好,且无不良反应,是一种安全有效的治疗方法。

Objective To study the efficiency and safety of gangliosides in the treatment of neonatal hypoxic‐ischemic en‐cephalopathy（HIE） ,so as to improve the clinical efficacy.Methods Fifty‐four cases of neonatal HIE in our hospital from Dec 2012 to Dec 2013 were selected as the study objects ,then divided them into observation group and control group by random double blind method.Comprehensive treatment was adopted in control group ,observation group was treated by gangliosides based on control group ,and nerve score ,NSE ,S1OOB level ,efficiency and safety of two groups after treatment were observed and compared.Results Differences of NBNA score in two groups had appeared gradually after treatment of 10 days ,of which observation group was higher than control group ;in the 28th day of treatment ,NBNA score difference increased ,serum NSE , S1OOB levels of observation group were higher than control group ,the differences between two groups were statistically signif‐icant ,P〈0.05.Conclusion The efficacy of gangliosides in the treatment of neonatal HIE is obvious ,without adverse reac‐tions ,it’s a safe and effective treatment for neonatal HIE.