摘要
[目的]继续对益母草(Leonurus japonicus Houtt.)的化学成分进行研究,为进一步开发利用该植物资源提供依据。[方法]采用正相硅胶、反相ODS、Sephadex LH-20等柱色谱及高效液相色谱法等方法进行分离纯化,并通过理化性质及光谱分析鉴定化合物的结构。[结果]从益母草体积分数为50%的乙醇提取物中分离鉴定了7个化合物,分别为(E)-4-hydroxy-dodec-2-enedioic acid(1)、益母草碱(2)、水苏碱(3)、次黄苷(4)、鸟苷(5)、左旋色氨酸(6)、苯丙氨酸(7)。[结论]1、4、5、7为从益母草种中首次分离得到的化合物。
[Objective] To investigate the chemical components of the herb Leonurus japonicus Houtt. Ⅲ.[Methods] The chemical components were obtained by chromatographies, such as silica gel, ODS, Sephadex LH-20 and HPLC. They were identified by the chemical and physical methods, especially spectral analysis. [Results] Seven compounds were obtained and identified as(E)-4-hydroxy-dodec-2-enedioic acid(1), leonurine(2), stachydrine(3),hypoxanthine-9-β-D-ribofuranoside(4), guanosine(5), L-tryptophan(6), and phenylalanine(7), respectively.[Conclusion] Compounds 1, 4, 5, and 7 are the obtained species firstly.
出处
《天津中医药大学学报》
CAS
2014年第6期362-365,共4页
Journal of Tianjin University of Traditional Chinese Medicine
基金
国家自然基金项目(81202995)
国家科技重大专项项目-重大新药创制(2011ZX09307-002-01)
新世纪优秀人才支持计划资助(NCET-12-1069
NCET-10-0958)
关键词
益母草
化学成分
结构鉴定
Leonurus japonicus Houtt.
chemical component
structural elucidation