STA Compact血凝仪在肝素抗凝治疗中的临床应用

Clinical Application of STA Compact Automatic Coagulometer in the Anticoagulation Therapy with Heparin

目的：利用STA Compact血凝仪对肝素抗凝治疗患者标本进行测定,给出肝素剂量在最佳抗凝效果时的活化部分凝血酶时间（activated partial thromboplastin time,APTT）和凝血酶原时间（prothrombin time,PT）参考范围.方法：检测应用肝素抗凝治疗的肺血栓塞患者的APTT和PT值,并以健康体检者作为对照组,利用STA Compact血凝仪测定,通过对测定结果的统计学分析,对肝素不同用量的抗凝效果进行评价.结果：（1）肝素治疗组肝素浓度与APTT呈正相关,与PT相关性较差.（2）测定APTT值可对肝素抗凝治疗进行监测.结论：在肝素抗凝治疗时,测定APTT值与正常对照值的1.22 ～2.24倍时,是抑制血栓形成,又不易发生出血等并发症的有效安全范围.

Objective： To assess the best diagnostic value of activated partial thromboplastin time （APTT） and prothrombm time （PT） determination for the patients with exemplar underwent anticoagulation therapy by STA Compact automatic coagulometer. Methods： The normal healthy people was selected as control group, the patient with anticoagulation therapy was enrolled as experimental group. Their value of APTT and PT were determinated, the results according to statistical analysis technique was assessed. Results： （ 1 ） The value of APTT were the positive correlation in the anticoagulation therapy with heparin. （ 2 ） The anticoagulation therapy with heparin could be monitored according to determination for the value of APTT. Conclusion： It is the most effective range that the value of APTT of the experimental group is 1.22 - 2. 24 times of control group in the anticoagulation therapy with heparin, so that the , thrombus is restrained.