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蛋白酶激活受体-1阻断剂对兔心肺复苏后脑损伤的保护作用

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摘要 心脏骤停后综合征（post—cardiac arrest syndrome，PCAS）是心肺复苏患者自主循环恢复后出现的多器官功能障碍综合征，病死率高、预后差，主要原因是心脏骤停后脑组织持续性损伤。心脏骤停心肺复苏的本质是全身缺血一再灌注损伤，脑组织对缺氧最敏感，因而最易损伤。
作者 杨敬宁 肖敏 王学军 梁鹏飞 柴林 罗明
机构地区 湖北医药学院附属太和医院急诊科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2015年第1期43-45,共3页 Chinese Journal of Emergency Medicine
基金 湖北省自然科学基金面上项目（2010CD809101）
关键词 蛋白酶激活受体-1 后脑损伤 心肺复苏 保护作用 多器官功能障碍综合征 阻断剂 心脏骤停 自主循环恢复
分类号 R459.7 [医药卫生—急诊医学]
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参考文献17

  • 1Cart BG, Kahn JM, Merchant RM, et al. Inter-hospital variability in post-cardiac arrest mortality [J]. Resuscitation, 2009, 80 (1): 30- 34.
  • 2Snyder-Ramos SA, Bottiger BW. Molecular markers of brain damage-clinical and ethical implications with particular focus on cardiac arrest [ J ]. Restor Neurol Neurosci, 2003, 21 ( 3/4 ) : 123-139.
  • 3Nishizawa Y. Glutamate release and neuronal damage in isehemia [J] . Life Sci, 2001, 69 (4): 369-381.
  • 4Hart KS, Mannaioni G, Hamill CE, et al. Activation of protease activated receptor 1 increases the exciability of the dentate granule neurons ofhippocampus [J]. Mol Brian, 2011, 4: 32-43.
  • 5肖敏,吕军,刘菊英,张绪国,罗明,陈静宜,李小燕,杨敬宁.心脏骤停后综合征动物模型的建立[J].中国急救医学,2010,30(6):532-536. 被引量：16
  • 6Laver S, Farrow C, Turner D, et al. Mode of death after admission to an intensive care unit following cardiac arrest [ J ] . Intensive Care Med, 2004, 30 (11) : 2126-2128.
  • 7Dohmen C, Kumura E, Rosner G, et al. Extracellular correlates of glutamate toxicity in short-term cerebral ischemia and reperfusion : a direct in vivo comparison between white and gray matter [ J ] . Brain Res, 2005 , 1037 (1/2): 43-51.
  • 8Charriaut-Marlangue C, Margaill I, Represa A, et al. Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis [J]. J Cereb Blood Flow Metab, 1996 , 16 (2) : 186-194.
  • 9Botfiger BW, Motsch J, Bohrer H, et al. Activation of blood coagulation after cardiac arrest is not balanced adequately by activation of endogenous fibrinolysis [ J]. Circulation, 1995, 92 (9) : 2572-2578.
  • 10Gando S, Nanzaki S, Morimoto Y, et al. Tissue factor and tissue factor pathway inhibitor levels during and after cardiopulmonary resuscitation [J]. Thrombosis Research, 1999, 96 (2): 107- 113.

二级参考文献43

  • 1宋凤卿,陈蒙华,谢露,何涛.延迟使用升压素与肾上腺素在窒息家兔心肺复苏中的疗效比较[J].中国急救医学,2005,25(9):662-664. 被引量：4
  • 2Cooper S, Janghorbani M, Cooper G. A decade of in-hospital resuscitation: outcomes and prediction of survival[J].Resuscitation, 2006,68(2):231-237.
  • 3Kern KB, Hilwig RW, Berg RA, et al. Efficacy of chest-compression only BLS CPR in the presence of an occluded airway[J].Resuscitation,1998,39(3):179-188.
  • 4Noc M, Weil MH, Tang W, et al.Mechanical ventilation may not be essential for initial cardiopulmonary resuscitation[J].Chest,1995,108(3):821-827.
  • 5Stiell IG, Wells GA, Field B, et al.Advanced cardiac life support in out-of-hospital cardiac arrest[J].N Engl J Med, 2004,351(7):647-656.
  • 6Lurie KG, Yannopoulos D, McKnite SH, et al. Comparison of a 10-breaths-per-minute versus a 2-breaths-per-minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrest[J].Respir Care, 2008,53(7):862-870.
  • 7Chen MH, Xie L, Liu TW, et al. Epinephrine, but not vasopressin, improves survival rates in an adult rabbit model of asphyxia cardiac arrest[J].Am J Emerg Med, 2007,25(5):509-514.
  • 8Guyton AC, Polizo D, Armstrong GG. Mean circulatory filling pressure measured immediately after cessation of heart pumping[J].Am J Physiol,1954,179(2):261-267.
  • 9XI G H, WAGNER K R,KEEP R F,et al. Role ofblood clot formation on early edema developmentafter experimental intracerebral hemorrhage [ J ].Stroke, 1998,29(12) :2580-2585.
  • 10LEE D Y,PARK KWJIN B K. Thrombin inducesneurodegeneration and microglial activation in thecortex in vivo and in vitro : Proteolytic and non-proteolytic actions [ J ]. Biochem Biophys ResComm,2006,346(3) :727-738.

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中华急诊医学杂志
2015年 第1期

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