灵芝三萜的生物合成和发酵调控

Biosynthesis and fermentation control of triterpenoids from Ganoderma lingzhi

灵芝作为一种名贵的药用真菌,在我国已有2 000多年的利用历史。灵芝三萜是灵芝的关键药效成分之一。从灵芝三萜的结构和构效关系、灵芝三萜的合成途径和相关关键酶,以及灵芝三萜的深层发酵调控策略和技术等方面,综述了灵芝三萜生物合成和发酵调控方面的新进展,进一步提出了当前存在的主要问题,并对今后的主要研究策略和研究方向进行了分析与展望。

Ganoderma triterpenoids are major pharmacologically active components in the fruiting bodies and mycelia of G. lingzhi. Structure‐activity relationship, basic biosynthetic pathways and key enzymes, as well as strategies and methods for the fermentation control of triterpenoids from G. lingzhi were reviewed. The main problems in biosynthesis and fermentation con‐trol of triterpenoids were put forward and the future research orientation and prospect were discussed.