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替吉奥联合紫杉醇脂质体与替吉奥联合紫杉醇在晚期胃癌化疗中疗效及不良反应观察

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摘要 目的:观察采用替吉奥联合紫杉醇与替吉奥联合紫杉醇脂质体联合方案在晚期胃癌化疗中疗效及不良反应的对比观察。方法:选择晚期胃癌患者40例,分为采用替吉奥联合紫杉醇脂质体方案的治疗组与采用替吉奥联合紫杉醇的对照组。3周为1个周期,至少完成2个周期,按RECIST1.1标准评价客观疗效,按NCI CTC3.0毒性评价标准不良反应。结果:所有患者均可评价疗效,无治疗相关性死亡事件发生,两组治疗有效率差异无统计学意义(P>0.05)。消化道反应、血液学毒性、过敏、外周神经毒性、肝肾功能损害等不良反应差异无统计学意义(P>0.05),但是对照组患者的脱发、肌肉及关节痛的发病率明显高于治疗组患者(P<0.05)。结论:替吉奥联合紫杉醇脂质体与替吉奥联合普通紫杉醇治疗晚期胃癌均取得了满意的临床疗效,两种治疗方案效果差异无统计学意义(P>0.05),但前者能够降低患者不良反应发病率,减轻化疗反应。
出处 《吉林医学》 CAS 2014年第35期7800-7801,共2页 Jilin Medical Journal
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