伯氏疏螺旋体BmpA诱导的莱姆关节炎中白细胞介素-6的变化

Change of IL-6 in Lyme Arthritis Induced by Bmp A of Borrelia burgdorferi

目的探究IL-6在莱姆关节炎发病中的变化.方法选取20只雌性昆明种小鼠,将其随机平均分为2组;用Bmp A蛋白液注射小鼠胫跗关节诱导莱姆关节炎;用ELISA法检测小鼠关节液IL-6的含量.结果注射蛋白液第10天时测得小鼠关节液中IL-6平均含量为72.26 pg/m L,而正常组小鼠关节炎IL-6平均含量为31.23 pg/m L.2组相关性检验时P<0.01,差异有统计学意义.结论 IL-6是重要的炎性细胞因子,与该病有着明显相关性,在莱姆关节炎的发病中起着重要作用.

Objective To investigate the change of IL-6 in Lyme arthritis. Methods Twenty female Kunming mice were selected and randomly divided into two groups. The recombinant BmpA of Borrelia burgdorferi was injected into the tibiotarsal joint of experimental group mice to induce the arthritis. ELISA experiment was used to detect the concentration of IL-6 in murine joints. Results The average concentration of IL-6 in the joint fluid of experimental mice and normal control group was 72.26 pg/mL and 31.32 pg/mL, respectively. The difference was statistically significant between two groups （P 〈 0.01） . Conclusion IL-6 is a important inflammatory cytokine, it has obvious correlation with Lyme arthritis.