糖尿病视网膜病变脂肪因子与血管病变相关因子关系的研究

Relationship of Adipokines and Vascular Disease Related Factors in Diabetic Retinopathy

目的探讨糖尿病视网膜病变脂肪因子与血管病变相关因子的关系.方法选择糖尿病及糖尿病视网膜病变(DR)患者86例,分为单纯糖尿病组(A组)、非增生型DR组(B组)、增生型DR组(C组),每组分别有31例、30例、25例.同时选择同期行健康体检的健康人群35例为D组.入选后分别检测各组血清内脂素、抵抗素、瘦素及MMP-2、MMP-9水平.结果 A组内脂素、抵抗素、瘦素较D组虽有变化差异无统计学意义(P>0.05),B组内脂素、抵抗素、瘦素较D组差异有统计学意义(P<0.05).C组抵抗素、瘦素较A、D组差异有统计学意义(P<0.05),内脂素较A、B、C组差异有统计学意义(P<0.05).A组患者MMP-2、MMP-9较D组虽有变化但差异无统计学意义(P>0.05).B组患者MMP-2、MMP-9较D组存在升高(P<0.05).C组患者MMP-2、MMP-9较A、D组差异有统计学意义(P<0.05).内脂素与MMP-2、MMP-9呈负相关(P<0.05).瘦素与抵抗素与MMP-2呈正相关(P<0.05).结论脂肪因子紊乱及MMP-2、MMP-9失调是DR发生的重要因素,纠正其代谢紊乱具有重要意义.

Objective To investigate the relationship of adipokines and vascular disease related factors in diabetic retinopathy. Methods Eighty-six patients with diabetes and/or diabetic retinopathy （DR） were divided into simple diabetic group （A, 31 cases） , non-proliferative DR group （B, 30 cases） and proliferative DR group （C, 25 cases） , with 35 healthy persons as control group （D） . The levels of serum visfatin, resistin, leptin, MMP-2 and MMP-9 in each group were measured. Results Compared with group D, the changes of visfatin, resistin, leptin, MMP-2 and MMP-9 levels in group A had no significant differences （P 〉 0.05） , while the levels of visfatin, resistin and leptin in group B showed significant differences （P 〈 0.05） , and the MMP-2 and MMP-9 levels increased significantly （P 〈 0.05） . There were significant differences in the levels of resistin, leptin, MMP-2 and MMP-9 between group C and groups A and D （P 〈 0.05） , and the level of visfatin in group A showed a significant difference compared with groups A, B and C （P 〈0.05） . Visfatin level was significantly negatively correlated with MMP-2 and MMP-9 （P 〈 0.05） , while levels of leptin, resistin and MMP-2 were significantly positively correlated （P 〈 0.05） Conclusion Adipokines disorders and imbalance expression of MMP-2 and MMP-9 are important factors for the occurrence of DR, so correcting their metabolic disorders is significant in the prevention and treatment of DR.