摘要
哺乳动物羧酸酯酶(carboxylesterase,CESs)是一个多基因家族,其基因产物定位于多种组织的内质网中.羧酸酯酶能有效催化酯类和酰胺类化合物水解,承担多种前体药物的生物转换功能药物.综述羧酸酯酶的结构、分类、生化性质、作用机制及其在抗肿瘤药物研究中的最新进展.
Mammalian carboxylesterases CESs represent a muhigene family, the products of which are localized in the endoplasmic reticulum of many tissues. CESs play an important role in the hydrolytic biotransformation of ester and amide-containing chemicals. A significant number of prodrugs are metabolized by carboxylesterase. This review covers current developments in the structure, function, biochemical characteristics, mechanisms and progress in the anti-tumor drug-researches of carboxylesterases.
出处
《昆明医科大学学报》
CAS
2015年第1期157-161,共5页
Journal of Kunming Medical University
基金
国家科技部重大新药创制专项基金资助项目(2011ZX09401-026)
关键词
羧酸酯酶
药物代谢
抗肿瘤药物
Carboxylesterases
Drug metabolism
Anti-tumor drug
