类风湿关节炎疾病活动度与气象因素的相关分析

Correlation analysis of the rheumatoid arthritis and the meteorological factors

目的 探讨RA疾病活动度与气象因素的相关性,为RA防治提供依据.方法 对所有入组的188例RA患者进行12个月的观察,每2周作为1个观测点,对每个观测点时就诊的RA患者进行DAS28及改良的Jamieson问卷评估;同时记录观测点期内的气象因素（气温、气压、相对湿度、风速）值.取气象因素的平均值与DAS28值进行Pearson双变量线性相关分析.对中重度RA的季节分布进行x2检验.结果 188例RA患者完成12个月观察,病情中度以上活动的RA患者164例,分布在冬季的有68例,显著高于其他三季（χ^2=9.42,P=0.022）.相关分析结果表明平均气温和平均风速与DAS28值呈负相关（r=-0.743,P＜0.01;r=-0.576,P=0.003）.结论 RA病情活动具有季节性特点,冬季RA容易加重,是多因素作用的结果,与温度、风速相关.创造适宜的局部温暖小气候环境有助于降低RA患者疾病活动度.

Objective To explore the relation between rheumatoid arthritis （RA） and the meteorological factors.Methods All RA cases in the group were followed for 12 months,patients were follow-up for every two weeks.In each followed-up,all RA cases were evaluated by the disease activity score-28 （DAS28） and the improved Jamieson questionnaire,and the correlation of the DAS28 and the average values of meteorolo-gical factors （temperature,humidity,atmospheric pressure,relative humidity,wind speed） by Pearson correlation coefficient.The moderate-severe activity cases were evaluated by chi-square test of different seasons.Results One hundred and eighty-eight cases completed the observation,One hundred and sixty-four cases were in moderate disease activities （χ^2=9.42,P=0.022）.Sixty-eight cases were distributed in winter,which was significantly higher than other three seasons.The average temperature and wind speed was negatively related to the DAS28 （r=-0.743,P〈0.01; r=-0.576,P=0.003）.Conclusion The activity of RA has the characteristics of seasonal changes,and is easily being aggravated in winter.Many factors may influence RA,including temperature and wind speed.Creating an appropriate micro-climate environment is beneficial for RA patients to reduce the disease activity.