期刊文献+

积极稳妥地进行治疗效果优化及新适应证探索研究,不断提高科学使用抗血管内皮生长因子药物治疗眼底病的临床应用水平 被引量:5

Optimization of treatment outcome and exploration of new indication in anti-vascular endothelial growth factor therapy
原文传递
导出
摘要 抗血管内皮生长因子(VEGF)药物治疗已经成为新生血管性老年性黄斑变性的临床一线治疗,在糖尿病黄斑水肿、视网膜静脉阻塞继发黄斑水肿以及早产儿视网膜病变、新生血管性青光眼等视网膜新生血管病变相关的疾病治疗中也得到广泛应用并取得良好的临床效果.然而,积极稳妥地进行治疗效果优化以及新的适应证探索研究,在国内外研究的基础上,结合本地区特点和患者具体情况,不断提高科学使用抗VEGF药物治疗眼底病的临床应用水平仍有大量工作要做;进一步深入研究新生血管性眼底疾病的本质特征以及影响其发生发展转归的相关因素,开发研究更新更好的治疗药物及方法尚任重道远. Since anti vascular endothelial growth factor (VEGF) therapy has recently become the first-line treatment of wet age related macular degeneration in China,as well as retinopathy of prematurity,neovascular glaucoma and macular edema secondary to diabetic retinopathy or retinal vein occlusion in other countries,It is worth thinking about that how to perform anti-VEGF treatment properly to benefit more patients.We reviewed the fields of clinical researches to explore the best role of anti-VEGF treatment in prevention and treatment of retinal disease in future.
作者 许迅
出处 《中华眼底病杂志》 CAS CSCD 北大核心 2015年第1期3-5,共3页 Chinese Journal of Ocular Fundus Diseases
关键词 血管生成抑制剂/治疗应用 抗体 单克隆/治疗应用 脉络膜新生血管化/药物疗法 视网膜新生血管化/药物疗法 Angiogenesis inhibitors/therapeutic use Antibodies, monoclonal/therapeutic use Choroidal neovascularization/drug therapy Retinal neovascularization/drug therapy
  • 相关文献

参考文献13

  • 1Ferrara N,Damico L,Shams N,et al.Development of ranibizumab,an anti-vascular endothelial growth factor antigen binding fragment,as therapy for neovascular age-related macular degeneration[J].Retina,2006,26(8):859-870.
  • 2Ip MS,Scott IU,Brown GC,et al.Anti-vascular endothelial growth factor pharmacotherapy for age-related macular degeneration:a report by the American Academy Of Ophthalmology[J].Ophthalmology,2008,115(10):1837-1846.
  • 3Brown DM,Michels M,Kaiser PK,et al.Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration:two-year results of the ANCHOR study[J].Ophthalmology,2009,116(1):57-65.
  • 4Regillo CD,Brown DM,Abraham P,et al.Randomized,double-masked,sham-controlled trial of ranibizumab for neovascular age-related macular degeneration:PIER study year 1[J].Am J Ophthalmol,2008,145(2):239-248.
  • 5Campochiaro PA,Hafiz G,Channa R,et al.Antagonism of vascular endothelial growth factor for macular edema caused by retinal vein occlusions:two-year outcomes[J].Ophthalmology,2010,117(12):2387-2394.
  • 6Do DV,Schmidt-Erfurth U,Gonzalez VH,et al.The DA VINCI study:phase 2 primary results of VEGF trap-eye in patients with diabetic macular edema[J].Ophthalmology,2011,118(9):1819-1826.
  • 7黎晓新.普及推广“中国老年性黄斑变性临床诊断治疗路径”,规范老年性黄斑变性的诊断治疗[J].中华眼底病杂志,2013,29(4):341-342. 被引量:25
  • 8Li X,Xu G,Wang Y,et al.Safety and efficacy of conbercept in neovascular age-related macular degeneration:results from a 12-month randomized phase 2 study:AURORA study[J].Ophthalmology,2014,121(9):1740-1747.
  • 9中国老年性黄斑变性临床诊断治疗路径[J].中华眼底病杂志,2013,29(4):343-355. 被引量:160
  • 10Heier JS,Brown DM,Chong V,et al.Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration[J].Ophthalmology,2012,119(12):2537-2548.

二级参考文献82

  • 1邹海东,张晳,许迅,汪枫桦,张世杰.上海市静安区曹家渡街道年龄相关性黄斑变性的患病率调查[J].中华眼科杂志,2005,4(1):15-19. 被引量:107
  • 2Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med, 2006,355 : 1419-1431.
  • 3Cheng Y, Huang L, Li X, et al. Genetic and functional dissection of ARMS2 in age-related macular degeneration and polypoidal choroidal vaseulopathy[J/OL]. PLoS One, 2013,8 : E53665 [ 2013-01-09 ]. http://www, plosone, org/article/info% 3Adoi%2F10. 1371 52Fjournal. pone. 0053665.
  • 4Jiang J, Huang L, Yu W, et al. Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs[J/OL]. PLoS ONE,2012,7: E46115 [2012-10-08] : http://www, plosone, org/article/info% 3Adoi% 2F10. 1371 %2Fjournal. pone. 0046115.
  • 5Li, Xiaoxin: Polypoidal Choroidal Retinopathy in the 5th Edition of RETINA, vol 71,p 1285, Elsevier, 2013.
  • 6CATT Research Group, Martin DF, Maguire MG, et al. Ranibizumab and bevaeizumab for neovaseular age-related maeular degeneration. N Engl J Med,2011,364: 1897-1908.
  • 7Ranibizumab and bevacizumab for treatment of neovascular age- related macular degeneration: two-year results, Ophthalmology, 2012,119 : 1388-1398.
  • 8Schmidt-Erfurth UM, Richard G, Augustin A, et al. Guidance for the treatment of neovascular age-related macular degeneration. Acta Ophthalmol Scand, 2007,85:486-494.
  • 9Heimes B, Lommatzsch A, Zeimer M, et al. Long-term visual course after anti-VEGF therapy for exudative AMD in clinical practice evaluation of the German reinjeetion scheme. Grade's Arch Clin Exp Ophthalmol, 2011, 249 : 639-644.
  • 10Lalwani GA, Rosenfeld PJ, Fung AE, et al. A variable-dosing regimen with intravitreal ranibizumab for neovaseular age-related maeular degeneration: year 2 of the PRONTO Study. Am J Ophthalmol, 2009,148 : 43-58.

共引文献174

同被引文献76

引证文献5

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部