miR-222在结直肠癌组织中的表达及意义

Expression and significance of miR-222 in colorectal cancer

目的探讨miRNA-222(miR-222)在结直肠癌组织中的表达及意义。方法采用实时定量PCR检测44例结直肠癌组织及癌旁正常组织中miR-222的表达水平,分析其与临床病理指标之间关系。结果 miR-222在44例癌组织标本中的表达量为0.0085(0.0041,0.0428),低于癌旁正常组织中的0.0188(0.0120,0.0326)(P<0.01)。miR-222在黏液性腺癌中的表达量为0.1461(0.0478,0.4251),低于非黏液性腺癌的0.4373(0.2012,1.1882)(P<0.05)。miR-222表达与患者的性别、年龄和结直肠癌的分化程度、临床分期、浸润深度、淋巴结和远处转移均无明显相关性(P>0.05)。结论 miR-222参与结直肠癌发生和发展的调控。

Objective To investigate the expression and significance of miRNA-222（miR-222）in colorectal cancer.Methods The expression of miR-222 in 44samples of colorectal cancer tissues and tumor-adjacent normal tissues was detected by qRT-PCR.Results The expression level of miR-222 was lower in colorectal cancer tissues than that in tumor-adjacent normal tissues[0.0085（0.0041,0.0428）vs.0.0188（0.0120,0.0326）]（P〈0.01）.miR-222 expression was lower in mucinous adenocarcinoma than that in nonmucinous adenocarcinoma[0.1461（0.0478,0.4251）vs.0.4373（0.2012,1.1882）]（P〈0.05）.miR-222 expression had no significant correlation with the gender and age,differentiation,classification,depth of invasion,lympho node and distant metasis of colorectal cancer（P〉0.05）.Conclusion miR-222 participates in the regulation of the occurrence and development of colorectal cancer.