检测PCT和CRP在哮喘合并呼吸道感染诊断和治疗的意义

Significance of procalcitonin and C reactive protein detection in diagnosis and treatment of asthma complicated with respiratory infection

目的探讨血清降钙素原(PCT)和C反应蛋白(CRP)在哮喘合并呼吸道感染中的临床意义。方法哮喘合并呼吸道感染患者120例均分为哮喘合并细菌感染(A)组和哮喘合并病毒感染(B)组,单纯哮喘患者60例作为对照(C组),测定并比较血清PCT和CRP水平。结果 A组血清PCT和CRP浓度为(26.5±8.7)μg/L和(50.1±18.6)mg/L,均高于B组的(0.6±0.2)μg/L和(5.8±0.6)mg/L和C组的(0.3±0.1)μg/L和(4.1±0.3)mg/L(P<0.01);A组血清PCT和CRP阳性检出率高于B、C组(P<0.01),B组高于C组(P<0.05)。结论哮喘合并细菌感染患者血清PCT和CRP水平明显升高,检测PCT和CRP可为临床使用抗菌药物提供参考依据。

Objective To investigate the role of detecting serum procalcitonin（PCT）and C reactive protein（CRP）in the diagnosis and treatment of asthma complicated with respiratory infection.Methods Serum PCT and CRP were detected in asthma complicated with respiratory bacterial infection（group A,60cases）,bronchial asthma complicated with respiratory virus infection（group B,60cases）and asthma without respiratory infection（group C,60cases）.Results Serum levels of PCT and CRP were（26.5±8.7）g/L and（50.1 ±18.6）mg/L in group A,which were significantly higher than（0.6±0.2）g/L and（5.8±0.6）mg/L in group B and（0.3±0.1）g/L and（4.1±0.3）mg/L in group C（P〈0.01）.Serum positive rate of PCT and CRP was higher in group A than that in groups of B and C（P〈0.01）,which was higher in group B than that in group C（P〈0.05）.Conclusion Serum levels of PCT and CRP are significantly increased in the asthma patients with respiratory bacterial infection.Combined detection of PCT and CRP can provide an useful reference for the use of antimicrobial drugs.