摘要
目的分析血管母细胞瘤(HB)临床病理特征。方法回顾性分析47例HB患者HE染色病理特征及SP法染色相关免疫组化标志物表达。结果肿瘤组织表现为特征性间质细胞及其之间丰富的毛细血管,血管壁衬覆扁平内皮细胞。肿瘤组织多阳性表达CD34、CD31、Vim、D2-40、NSE、S100、CD56、EGFR和VEGF,多阴性表达EMA、CK和GFAP。散发性HB患者免疫阳性表达率与VHL相关性HB患者相仿(P>0.05)。结论结合HE染色病理特征及相关标志物表达有助于诊断HB。
Objective To analyze the clinicopathologic features of hemangioblastomas（HB）.Methods Clinicopathologic features（HE stainning）and expressions of related immunohistochemical markers（SP method）of 47 HB patients were retrospectively analyzed.Results HB tissues showed a typical type of stroma cells with rich capillaries lined by flattened endothelial cells.Majority of HB tissues positively expressed CD34,CD31,Vim,D2-40,NSE,S100,CD56,EGFR and VEGF,but negatively expressed EMA,CK and GFAP.The positive expression rate of immune markes in sporadic HB patients was similar to that in von Hippel-Lindau（VHL）syndrome-related HB patients（P〉0.05）.Conclusion Combined analysis of HE stainning pathological features and the expressions of related markers can be helpful in the diagnosis of HB.
出处
《江苏医药》
CAS
2015年第1期63-65,F0002,共4页
Jiangsu Medical Journal
