急性冠状动脉综合征患者血浆IL-18结合蛋白和IL-18水平变化及意义

Elevated plasma IL-18 binding protein and IL-18 levels in patients with acute coronary syndrome

目的:探讨急性冠状动脉综合征(ACS)患者血浆白细胞介素(IL)-18结合蛋白和IL-18水平的变化。方法:连续入选稳定型心绞痛(SAP)组(50例),不稳定型心绞痛(UAP)组(75例)和急性心肌梗死(AMI)组(67例)。同期冠状动脉(冠脉)造影正常的65例患者为对照组。采用夹心酶联免疫法(ELISA)测定血浆IL-18结合蛋白和IL-18水平。结果:SAP组、UAP组和AMI组血浆IL-18和IL-18结合蛋白水平显著高于对照组,UAP组和AMI组血浆IL-18和IL-18结合蛋白水平显著高于SAP组。冠心病患者IL-18结合蛋白水平与IL-18、C反应蛋白(CRP)、左室舒张末期内径(LVEDD)正相关,与左室射血分数(LVEF)显著负相关。结论:血浆IL-18结合蛋白和IL-18水平变化可能与ACS的出现密切相关。

Objective：To evaluate the levels of IL-18 binding protein and IL-18 in patients with acute coronary syndrome（ACS）.Method：The plasma IL-18 binding protein and IL-18 levels were measured in 50 patients with stable angina pectoris（SAP）,75 patients with unstable angina pectoris（UAP）,67 patients with acute myocardial infarction（AMI）and 65 control patients.Result：The plasma IL-18 binding protein and IL-18 levels were significantly higher in the AMI,SAP and UAP groups than in the control group.And plasma IL-18 binding protein and IL-18 levels were significantly higher in the AMI and UAP groups than in the SAP group.A correlation analysis showed that the plasma IL-18 binding protein levels were positively correlated with IL-18,CRP and LVEDD,but negatively correlated with LVEF.Conclusion：The results indicate that the plasma IL-18 binding protein and IL-18 levels are associated with the onset of ACS symptoms.