类风湿关节炎静息态功能磁共振研究

Study of resting-state functional MRI in patients with rheumatoid arthritis

目的:探讨类风湿关节炎(RA)患者静息态下局部脑区的自发神经活动。方法:利用3.0T磁共振扫描仪采集年龄、性别及受教育程度相匹配的35例RA患者(RA组)和35例正常对照者(NC组)静息态功能磁共振(rs-fMRI)数据,应用低频振幅(ALFF)方法分析、比较两组受试者大脑自发活动的差异。结果:与正常对照组相比,RA患者ALFF值增高区位于双侧前扣带膝下部、双内侧眶额皮层以及双侧岛叶,ALFF值降低区主要位于双侧距状回、右舌回、右楔叶、左枕中回(P<0.05,AlphaSim校正)。结论:RA患者静息态下神经活动存在异常,增高区可能反映与疾病相关的运动决策功能改变,功能降低区可能反映视觉功能改变。

Objective：To study the spontaneous neural activity in local cerebral regions during resting state in patients with rheumatoid arthritis.Methods3.0T MRI was used for data acquisition.fMRI data were acquired during resting state in 35 patients with rheumatoid arthritis（RA group）and 35 heatlhy controls（NC group）matched at age,gender and education level,The discrepancies of spontaneous neural activity between the two groups were compared and analyzed using amplitude of low frequency fluctuation（ALFF）.Results：Compared with NC group,the value of ALFF in RA group was significantly increased in bilateral subgenual cingulate,bilateral medial orbitofrontal cortex and bilateral insula,the value of ALFF was decreased mainly located in bilateral calcarine gyrus,right lingual gyrus,right cuneus and left middle occipital gyrus（P〈0.05,AlphaSim corrected）.Conclusion：Abnormal brain activity exists in RA patients during resting state,the increased regions might response to the changes of decision-making function on movement related to the disease,the decreased regions might reflect the changes of visual function.