妊娠期高脂血症患者SOD活性及MDA、NO含量的变化

The Changes of Activity of SOD and Amount of MDA,NO for Hyperlipoidemia Patients During Pregnancy

目的:检测妊娠期高脂血症患者血浆超氧化物歧化酶(SOD)、丙二醛(MDA)和一氧化氮(NO)含量,寻找监测妊娠高脂血症的临床指标。方法:采集45例妊娠期高脂血症患者血浆和50例正常孕妇血浆,以硫代巴比妥酸(TBA)比色法、黄嘌呤氧化酶法、硝酸还原酶法分别测定SOD、MDA、NO的含量。结果:妊娠期高脂血症组血浆SOD活性、NO的含量明显低于对照组,MDA含量明显高于对照组,两组比较差异均有统计学意义(P<0.05)。结论:SOD、MDA、NO的变化与妊娠高脂血症的病理变化有关,检测其含量可作为临床监测妊娠高脂血症病情的指标。

Objective： To measure the amount of superoxide dismutase（SOD）, malondialdehyde（MDA） and nitric oxide（NO）, and to try to find out the clinical index for monitoring hypcrlipoidemia during pregnancy.Method ： The blood plasma was collected respectively from 45 gestational hyperlipidemia patients and 50 normal pregnant women.And respectively measure the amount of SOD, MDA, NO with TBA, xanthine oxidase, nitrate reductase.Result： The activity of SOD and amount of NO were significantly lower than the control group（P〈0.05）.The amount of MDA was much higher in gestational hyperlipidcmia women, ~ompared with control group（P〈0.05）.Conclusion： The change of the amount of SOD, MDA, NO maybe concern with the pathological changes of gestational hyperlipidemia, the amount detection can be regarded as index for monitoring gestational hyperlipidemia.