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急性髓系白血病中的异柠檬酸脱氢酶基因突变

Isocitrate dehydrogenase mutation in acute myeloid leukemia
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摘要 异柠檬酸脱氢酶（isocitrate dehydrogenase,IDH）在细胞内催化异柠檬酸氧化脱羧生成α-酮戊二酸（α-KG）,将NADP＋还原生成NADPH.IDH1与IDH2分布于不同的亚细胞结构中.IDH1分布于胞质及过氧化物酶体中,参与脂类及糖类代谢,为细胞提供NADPH,保护细胞免受反应氧簇（reactive oxygen species,ROS）及辐射损伤;IDH2分布于线粒体中,参与三羧酸循环,保护细胞免受氧化损伤.
作者 张轶群 杨林花
机构地区 山西医科大学第二医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2015年第1期82-84,共3页 Chinese Journal of Hematology
关键词 异柠檬酸脱氢酶 急性髓系白血病 酶基因突变 过氧化物酶体 α-酮戊二酸 亚细胞结构 NADPH 三羧酸循环
分类号 R733.71 [医药卫生—肿瘤]
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参考文献32

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二级参考文献54

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中华血液学杂志
2015年 第1期

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