氨磺必利治疗首发精神分裂症的泌乳素水平与临床疗效分析

The effect of amisulpride on prolactin level and clinical efficacy in first-episode schizophrenic patients

目的探讨氨磺必利对首发精神分裂症患者血清泌乳素水平的影响及其与症状的关系。方法对符合DSM—IV精神分裂症诊断标准的45例患者和年龄、性别相匹配的45例健康对照，用阳性和阴性症状量表（PANSS）进行症状评定，利用酶联免疫法进行泌乳素水平测定，用配对t检验比较患者氨磺必利治疗前后血清泌乳素水平，用相关性分析研究血清泌乳素水平与症状的关系。结果首发精神分裂症患者氨磺必利治疗后血清泌乳素水平较治疗前显著升高[（12．52±8．85）ng／ml，（52．60±22．93）ng／m1，t=12．165，P〈0．001]；患者治疗后血清泌乳素水平与阴性症状分减分率呈正相关（r=0．24，P〈0．05）。结论氨磺必利能引起血清泌乳素升高；血清泌乳素升高与阴性症状改善密切相关。

Objective To discuss the effect of amisulpride on the prolactin level in serum of first-episode schizophrenic patients and its relationship with symptoms. Methods 45 patients who met the DSM-IV schizo- phrenia diagnostic criteria and 45 age- and gender- matched healthy controls were assessed the clinical symptoms using positive and negative syndrome scale（PANSS） and prolactin level in serum was detected using enzymelinked immunosorbent assay. Student＇s t test was used to compare the prolaetin level before and after amisulpride treatment and correlation analysis was used to investigate the relationship between prolactin level in serum and symptoms with P〈0.05 were considered significantly different. Results There was significant increase in prolactin level in serum after amisulpride treatment in first-episode schizophrenic patients（ （12.52±8.85） ng/ml, （52.60±22.93 ng/ml, t= 12.165, P〈0.001 ）.There was a positive correlation between prolactin level in serum and reduction rate of negative symptoms（ r= 0.24, P〈0.05）.Conclusion Amisulpride can increase prolaetin level in serum;and the rise of serum prolactin is closely related to the improvement of negative symptoms.